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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lipase-catalysed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent.

Ammonium, provided by ammonium carbamate as a novel acyl acceptor, was adopted for enzymic enantioselective ammonolysis of racemic phenylglycine methyl ester in this paper and it has been found that the reaction conditions have profound effects on enzymic activity and enantioselectivity: the optimal concentration of ammonium carbamate was 80 mM; t-butanol was the most suitable reaction medium and the optimum initial water activity was found to be 0.75; relatively high reaction rate and enantioselectivity could be attained within the temperature range of 30-40 degrees C. Compared with the corresponding hydrolysis and alcoholysis, enzymic ammonolysis expressed rather high enzymic activity and enantioselectivity and 95% of enzymic activity remained after 10 batches of ammonolysis, which demonstrates that lipase-catalysed ammonolysis is a promising method for the preparation of optically pure (R)-phenylglycine and its derivatives.[1]


  1. Lipase-catalysed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent. Du, W., Zong, M., Guo, Y., Liu, D. Biotechnol. Appl. Biochem. (2003) [Pubmed]
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