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Chemical Compound Review

LS-48943     azanium carbamate hydrate

Synonyms: AC1L23C8
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Disease relevance of HSDB 485

  • The formation of "ammonium carbamate" corresponds to an almost thermoneutral process, whereas its dehydration, which is the rate-determining step, is highly endothermic [1].

High impact information on HSDB 485

  • An intramolecular H-bond between ester and ammonium-carbamate group was suggested to be important for the permeation-enhancing activity of T12 [2].
  • Lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester was processed by in situ racemization with ammonium carbamate as the acyl acceptor [3].
  • In this work, it is demonstrated that ammonium carbamate in combination with poly(ethylene glycol) (PEG, molecular masses of 2000, 4000 and 10000) indeed produces aqueous two-phase systems (ATPSs) at a temperature of 25 degrees C and atmospheric pressure [4].


  1. Mechanistic insights into the Bazarov synthesis of urea from NH3 and CO2 using electronic structure calculation methods. Tsipis, C.A., Karipidis, P.A. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  2. Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12. Holas, T., Vávrová, K., Klimentová, J., Hrabálek, A. Bioorg. Med. Chem. (2006) [Pubmed]
  3. Improving lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent by in situ racemization. Du, W., Zong, M., Guo, Y., Liu, D. Biotechnol. Lett. (2003) [Pubmed]
  4. Poly(ethylene glycol)-salt aqueous two-phase systems with easily recyclable volatile salts. van Berlo, M., Luyben, K.C., van der Wielen, L.A. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
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