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Shimizu, E. et al.

Shimizu, Hashimoto, Salama, Watanabe, Komatsu, Okamura, Koike, Shinoda, Nakazato, Kumakiri, Okada, Muramatsu, Muramatsu, Iyo,

Two clusters of serum midkine levels in drug-naive patients with schizophrenia.

Midkine ( MK) is a heparin-binding growth factor implicated in various biological phenomena such as development of the hippocampus and anxiety. We evaluated serum MK levels of drug-naive (n=15) and medicated (n=25) patients with schizophrenia, and age- and sex-matched normal controls (n=38). The patients showed two clusters in the levels. Four drug-naive patients (26.7%) and two medicated patients (8.0%) had abnormally high values, but no controls did, there being a significant difference in the numbers (P=0.003, Fisher's exact test). Furthermore, in other patients, the mean MK levels in drug-naive schizophrenia (0.30+/-0.10 ng/ml) were significantly (P=0.018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia.[1]

References

Two clusters of serum midkine levels in drug-naive patients with schizophrenia. Shimizu, E., Hashimoto, K., Salama, R.H., Watanabe, H., Komatsu, N., Okamura, N., Koike, K., Shinoda, N., Nakazato, M., Kumakiri, C., Okada, S., Muramatsu, H., Muramatsu, T., Iyo, M. Neurosci. Lett. (2003) [Pubmed]

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