The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Biological Phenomena

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Biological Phenomena

  • We propose that reorganization of keratin by SPC may facilitate biological phenomena that require a high degree of elasticity, such as squeezing of cells through membranous pores during metastasis [1].
  • Circumstantial evidence has been provided of a role of the plasminogen/plasmin system in a variety of biological phenomena, including thrombolysis, vascular stenosis, reproduction, embryogenesis, cell invasion, angiogenesis, brain function and chronic lung or kidney inflammatory disorders [2].
  • CONCLUSION: Findings such as those illustrated in this study occur in virtually all biologic phenomena and they do not invalidate the very high degree of correlation between the expression of E-cadherin and the classification of breast carcinomas as ductal or lobular type on the basis of conventional histologic criteria [3].

Psychiatry related information on Biological Phenomena

  • For example, drug abuse treatment and prevention strategies could be explored using tobacco use as a target behavior, and biological phenomena such as the development of tolerance and physical dependence may be more readily studied with nicotine than with many other drugs [4].

High impact information on Biological Phenomena

  • RGS proteins are negative regulators of signaling through heterotrimeric G protein-coupled receptors and, as such, are in a position to regulate a plethora of biological phenomena [5].
  • Syndecan-1 is constitutively expressed by several epithelial cells, but expression is also induced during many biological phenomena, such as tissue regeneration and the epithelial-mesenchymal interactions during organ development [6].
  • As ZDS1 and ZDS2 have recently been identified also by numerous other groups studying a wide range of biological phenomena, the roles of Cdc42p in intracellular signaling may be more diverse than has previously been appreciated [7].
  • It has been reported that AML1 plays several pivotal roles in myeloid hematopoietic differentiation and other biological phenomena, probably through the transcriptional regulation of various relevant genes [8].
  • Furthermore, we show the feasibility of simultaneous multichannel measurements of distinct biological phenomena such as receptor tyrosine kinase expression and angiogenesis [9].

Biological context of Biological Phenomena


Anatomical context of Biological Phenomena


Associations of Biological Phenomena with chemical compounds

  • Sialic acid-containing glycosphingolipids (gangliosides) have been implicated in the regulation of various biological phenomena such as atherosclerosis [20].
  • Integrin alpha(5)beta(1), a major fibronectin receptor, functions in a wide variety of biological phenomena [21].
  • New models of schizophrenia mimic biological phenomena associated with the clinical condition, particularly developmental changes in the cortex, abnormalities of glutamate neurotransmission, and genetic characteristics of selected behavioral traits [22].
  • Both these biological phenomena are, therefore, tightly linked to the amplitude and duration of the Ca(2+) transient, a signal decoded downstream by Ca(2+)-dependent transcriptional pathways [23].
  • For the study of biological phenomena influenced by the R- and N-Ras proteins, characteristic peptides which embody the correct lipid modifications of their parent proteins (palmitoyl thioesters, geranylgeranyl thioethers, and farnesyl thioethers), as well as analogues thereof, may serve as efficient tools [24].

Gene context of Biological Phenomena


  1. Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells. Beil, M., Micoulet, A., von Wichert, G., Paschke, S., Walther, P., Omary, M.B., Van Veldhoven, P.P., Gern, U., Wolff-Hieber, E., Eggermann, J., Waltenberger, J., Adler, G., Spatz, J., Seufferlein, T. Nat. Cell Biol. (2003) [Pubmed]
  2. Alpha2-antiplasmin on cardiovascular diseases. Matsuno, H. Curr. Pharm. Des. (2006) [Pubmed]
  3. Aberrant E-cadherin staining patterns in invasive mammary carcinoma. Harigopal, M., Shin, S.J., Murray, M.P., Tickoo, S.K., Brogi, E., Rosen, P.P. World journal of surgical oncology [electronic resource]. (2005) [Pubmed]
  4. Involvement of tobacco in alcoholism and illicit drug use. Henningfield, J.E., Clayton, R., Pollin, W. British journal of addiction. (1990) [Pubmed]
  5. Generation and characterization of Rgs4 mutant mice. Grillet, N., Pattyn, A., Contet, C., Kieffer, B.L., Goridis, C., Brunet, J.F. Mol. Cell. Biol. (2005) [Pubmed]
  6. Transcriptional regulation of Syndecan-1 expression by growth factors. Jaakkola, P., Jalkanen, M. Prog. Nucleic Acid Res. Mol. Biol. (1999) [Pubmed]
  7. ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Bi, E., Pringle, J.R. Mol. Cell. Biol. (1996) [Pubmed]
  8. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability. Tanaka, T., Kurokawa, M., Ueki, K., Tanaka, K., Imai, Y., Mitani, K., Okazaki, K., Sagata, N., Yazaki, Y., Shibata, Y., Kadowaki, T., Hirai, H. Mol. Cell. Biol. (1996) [Pubmed]
  9. Tomographic fluorescence mapping of tumor targets. Montet, X., Ntziachristos, V., Grimm, J., Weissleder, R. Cancer Res. (2005) [Pubmed]
  10. Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase. Guimarães, M.J., Bazan, J.F., Castagnola, J., Diaz, S., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Varki, A., Zlotnik, A. J. Biol. Chem. (1996) [Pubmed]
  11. High-throughput scintillation proximity assay for transglutaminase activity measurement. Mádi, A., Kárpáti, L., Kovács, A., Muszbek, L., Fésüs, L. Anal. Biochem. (2005) [Pubmed]
  12. Calmodulin-dependent phosphorylation and dephosphorylation during fertilization in Dictyostelium discoideum. Lydan, M.A., O'Day, D.H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  13. Standardization of a method for characterizing low-concentration biogels: elastic properties of low-concentration agarose gels. Benkherourou, M., Rochas, C., Tracqui, P., Tranqui, L., Guméry, P.Y. Journal of biomechanical engineering. (1999) [Pubmed]
  14. Spring snow lowers human melatonin. Leppäluoto, J., Sikkilä, K., Meyer-Rochow, V.B., Hassi, J. International journal of circumpolar health. (2004) [Pubmed]
  15. Asn-linked oligosaccharide-dependent interaction between laminin and gp120/140. An alpha 6/beta 1 integrin. Chammas, R., Veiga, S.S., Line, S., Potocnjak, P., Brentani, R.R. J. Biol. Chem. (1991) [Pubmed]
  16. Processing of viral envelope glycoprotein by the endomannosidase pathway: evaluation of host cell specificity. Karaivanova, V.K., Luan, P., Spiro, R.G. Glycobiology (1998) [Pubmed]
  17. Two clusters of serum midkine levels in drug-naive patients with schizophrenia. Shimizu, E., Hashimoto, K., Salama, R.H., Watanabe, H., Komatsu, N., Okamura, N., Koike, K., Shinoda, N., Nakazato, M., Kumakiri, C., Okada, S., Muramatsu, H., Muramatsu, T., Iyo, M. Neurosci. Lett. (2003) [Pubmed]
  18. Expression of size-polymorphic androgen receptor (AR) gene in ovarian endometriosis according to the number of cytosine, adenine, and guanine (CAG) repeats in AR alleles. Fujimoto, J., Hirose, R., Sakaguchi, H., Tamaya, T. Steroids (1999) [Pubmed]
  19. Searching for stem cell regulatory molecules. Some general thoughts and possible approaches. Lemischka, I. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  20. Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. Moon, S.K., Kim, H.M., Lee, Y.C., Kim, C.H. J. Biol. Chem. (2004) [Pubmed]
  21. Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectin. Nadanaka, S., Sato, C., Kitajima, K., Katagiri, K., Irie, S., Yamagata, T. J. Biol. Chem. (2001) [Pubmed]
  22. To model a psychiatric disorder in animals: schizophrenia as a reality test. Lipska, B.K., Weinberger, D.R. Neuropsychopharmacology (2000) [Pubmed]
  23. The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. Chin, E.R. The Proceedings of the Nutrition Society. (2004) [Pubmed]
  24. Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N-Ras proteins. Schmittberger, T., Waldmann, H. Bioorg. Med. Chem. (1999) [Pubmed]
  25. Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells. Sudo, T., Yagasaki, Y., Hama, H., Watanabe, N., Osada, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  26. Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. Di Sano, F., Fazi, B., Citro, G., Lovat, P.E., Cesareni, G., Piacentini, M. Cancer Res. (2003) [Pubmed]
  27. Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery. Kimura, S.H., Ikawa, M., Ito, A., Okabe, M., Nojima, H. Oncogene (2001) [Pubmed]
  28. p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression. Sudo, T., Kawai, K., Matsuzaki, H., Osada, H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  29. Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells. Lison, D., Knoops, B., Collette, C., Lauwerys, R. Biochem. Pharmacol. (1989) [Pubmed]
WikiGenes - Universities