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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A novel enantioselective alkylation and its application to the synthesis of an anticancer agent.

A novel enantioselective alkylation of double benzylic substrates with secondary electrophiles is reported. A simple norephedrine-based chiral ligand was synthesized that gives alkylation product in 95% yield and 95% ee. A unique water effect on the enantioselectivity was unveiled. Good to excellent ee values were obtained with a number of double benzylic substrates and secondary electrophiles. This novel reaction has been applied to the synthesis of a promising anticancer agent.[1]

References

  1. A novel enantioselective alkylation and its application to the synthesis of an anticancer agent. Kuo, S.C., Chen, F., Hou, D., Kim-Meade, A., Bernard, C., Liu, J., Levy, S., Wu, G.G. J. Org. Chem. (2003) [Pubmed]
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