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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Absence of one component of spectrin adenosine triphosphatase in hereditary spherocytosis.

The stimulation by calcium and magnesium of ATPase activity of isolated ghosts, of water-soluble protein (spectrin), and of residual vesicles, derived from normal erythrocytes and from hereditary spherocytes (H.S.), has been measured. The ATPase activity found in normal water-soluble protein (WSP) at low levels of calcium (0.1-2.0 mM) is essentially absent in H.S. water-soluble protein, but the ATPase activity with magnesium and with high levels of calcium (60-100 mM) is the same in H.S. and normal WSP. Compared to normal, H.S. ghosts have increased Mg2+-stimulated activity. This increased activity is retained by the sedimentable vesicles ("residue") after extraction of the ghosts with 0.025 mM EDTA. The Ca2+, Mg2+-ATPase associated with the calcium pump is not significantly different in H.S.[1]


  1. Absence of one component of spectrin adenosine triphosphatase in hereditary spherocytosis. Kirkpatrick, F.H., Woods, G.M., La Celle, P.L. Blood (1975) [Pubmed]
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