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Chemical Compound Review

Edetates     2-[2-(bis(carboxymethyl) amino)ethyl...

Synonyms: Edathamil, Versenate, Versene, Tetracemate, EDTA, ...
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Disease relevance of Edathamil

  • Here we describe the use of a nontoxic, copper-specific chelating agent, bathocuproine sulphonate (Fig. 1) which, by combining with available endogenous copper in a tissue culture preparation, abolished the toxicity of three structurally unrelated chelating agents [1].
  • This review focuses on the evolution of iron chelators from initial lead compounds through to the development of novel chelating agents, many of which show great potential to be clinically applied in the treatment of iron overload disease and cancer [2].
  • Investigation suggested that pediatric-sized vacuum tubes containing ethylenediamine tetraacetic acid (EDTA) were the source of the organisms, and the epidemic strain of Serratia was recovered from 41 (35%) of the 116 tubes cultured [3].
  • Dissolution of pellets prepared from human gallstones and composed predominantly of either calcium bilirubinate or calcium carbonate was 80% and 85% at 4 h using ethylenediaminetetraacetic acid 1% plus polysorbate-20 1% at pH 9 [4].
  • Effect of immunologic reactions on rat intestinal epithelium. Correlation of increased permeability to chromium 51-labeled ethylenediaminetetraacetic acid and ovalbumin during acute inflammation and anaphylaxis [5].

Psychiatry related information on Edathamil


High impact information on Edathamil


Chemical compound and disease context of Edathamil


Biological context of Edathamil

  • The study was carried out in the absence of chelating agents because they strongly interfere in the enzyme kinetics [18].
  • Ethylenediaminetetraacetic acid prevented cell adhesion in the presence of divalent cations [19].
  • After long-term incubation of cells with these metal-chelating agents under conditions in which cell viability is not impaired but proliferation is retarded, the rate of DNA synthesis of EDTA-exposed cells is the same as that of untreated controls, whereas the rate of DNA synthesis of 1,10-phenanthroline-exposed cells is markedly reduced [20].
  • Effects of ethylenediaminetetraacetic acid and 1,10-phenanthroline on cell proliferation and DNA synthesis of Ehrlich ascites cells [20].
  • The rapid direct effect of 1,10-phenanthroline upon cells in S phase is consistent with the finding that a large fraction of this metal-binding ligand but not of EDTA can be readily taken up by cells [20].

Anatomical context of Edathamil


Associations of Edathamil with other chemical compounds


Gene context of Edathamil


Analytical, diagnostic and therapeutic context of Edathamil


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