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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells.

Hemopexin (Hx) is an acute-phase hepatic protein, whose transcription is upregulated by IL-6. The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells. Insulin did not affect the transcription rate of Hx. These findings are consistent with involvement of intracellular calcium concentrations and activation of protein kinase C ( PKC) action in the regulation of Hx.[1]

References

  1. Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells. Stred, S.E., Cote, D., Weinstock, R.S., Messina, J.L. Mol. Cell. Endocrinol. (2003) [Pubmed]
 
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