The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Ancans, J. et al.

Ancans, Flanagan, Hoogduijn, Thody,

P-locus is a target for the melanogenic effects of MC-1R signaling: a possible control point for facultative pigmentation.

Melanocortin receptor type 1 (MC-1R) is an important control point for ultraviolet ray (UVR)-induced tanning response in the skin. In this study, we show that p-locus is a downstream target for MC-1R signaling. The expression of p-locus was up-regulated by alpha-MSH as well as db-cAMP, a synthetic analogue of cAMP that mimics activation of MC-1R. Furthermore, p-locus transcript abundance was significantly increased in epidermal melanocytes of white skin with facultative (UVR-induced) pigmentation. Because p-locus product is essential for pigmentation and also has been shown to be highly polymorphic in human population, we propose that the pigmentary response to the melanocortin peptides/UVR would be affected not only by MC-1R mutations but also by the functionality of p-locus product. These factors together could account for the many different levels of tanning ability seen in the white population.[1]

References

P-locus is a target for the melanogenic effects of MC-1R signaling: a possible control point for facultative pigmentation. Ancans, J., Flanagan, N., Hoogduijn, M.J., Thody, A.J. Ann. N. Y. Acad. Sci. (2003) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg