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Solubilities of phenazopyridine, propranolol, and methimazole in supercritical carbon dioxide.

The equilibrium solubilities of three drugs (phenazopyridine, propranolol and methimazole) were determined at temperatures ranging from 308 to 348 K and pressures from 122 to 355 bar in supercritical CO2 by a simple and reliable static method. The crossover region was observed for phenazopyridine, propranolol and methimazole at 180 bar. The solubilities were correlated using a semi empirical model. Correlation of the results shows good self-consistency of the data obtained.[1]

References

  1. Solubilities of phenazopyridine, propranolol, and methimazole in supercritical carbon dioxide. Yamini, Y., Arab, J., Asghari-Khiavi, M. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
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