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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Solubility

  • These experiments were conducted with a 10-microm marine scuticociliate (Uronema sp.), bacterial prey (Halomonas halodurans), and a suite of 21 CB congeners spanning a range of aqueous solubilities [1].
  • Cr(III) and Cr(VI) compounds of varying solubilities have been tested in vitro for their ability to inhibit cell growth and nucleic acid and protein syntheses in BHK cells, to induce alterations in the mitotic cycle in HEp cells, and to increase the frequency of chromosomal aberrations and sister chromatid exchanges (SCE) in CHO cells [2].
  • The solubilities of CGS and CIS were relatively low and similar at both pH levels and do not readily explain the observed differences in pulmonary toxicity [3].
  • The observed inhibition of two membrane functions by the polycyclic aromatic hydrocarbons does not correlate simply with their theoretical octanol/water partition coefficients, water solubilities, or ability to confer membrane stabilization against osmotic hemolysis [4].

High impact information on Solubility


Chemical compound and disease context of Solubility

  • The biodegradabilities of glycol- and acetate-based aircraft de-icing fluids on airport surfaces have been investigated at three temperatures between 0 degrees C and 10 degrees C. The aqueous solubilities of these substances can result in high BOD loadings in runoff and pose serious toxicity problems in receiving waters [10].

Biological context of Solubility


Anatomical context of Solubility


Associations of Solubility with chemical compounds

  • The relative solubilities of liver collagen in 8 M urea: 10 mM dithiothreitol were greater in treated animals as compared to controls [21].
  • This report describes a rigorous physical-chemical approach to determine the solubilities of unconjugated bilirubin in model bile systems [22].
  • Also, the three preparations containing cysteine substituted collagens had higher solubilities than normal type I collagen [23].
  • Tetrameric deoxy-Hbs containing tryptophan or phenylalanine at the beta 6 position had higher solubilities and polymerized less readily compared with deoxy-Hb S [24].
  • The transglycosylation yields to benzyl beta-GlcNAc (67%), 4-methyl-umbelliferyl beta-GlcNAc (66%), p-nitrophenyl beta-GlcNAc (33%), and (GlcNAc-beta-S-CH2CH2CH2)2 (43%) were lower, because their poor solubilities allowed only 0.05 M or lower concentrations in the reaction mixture [25].

Gene context of Solubility

  • Their solubilities and secondary structures in solution and in the solid state have been used to detect differences between the properties of human and rodent beta A4 sequences [26].
  • Examination of the Triton X-100 solubilities of occludin and several nonmembrane TJ proteins revealed a shift of occludin and nonmembrane TJ proteins into an insoluble pool following ATP depletion [27].
  • Due to their differential solubilities in NaCl and (NH4)2SO4 solutions, individual alpha and beta subunit pools of CKII could be detected [28].
  • O-Mannosylation increases solubilities of the aberrant proteins and renders them less dependent on the ER chaperone, BiP, for being soluble [29].
  • The solubilities of all eight vertebrate proteins examined including transcription factors and kinases were increased dramatically by coproduction of Trx [30].

Analytical, diagnostic and therapeutic context of Solubility


  1. Importance of passive diffusion in the uptake of polychlorinated biphenyls by phagotrophic protozoa. Kujawinski, E.B., Farrington, J.W., Moffett, J.W. Appl. Environ. Microbiol. (2000) [Pubmed]
  2. Cytotoxic and clastogenic effects of soluble and insoluble compounds containing hexavalent and trivalent chromium. Levis, A.G., Majone, F. Br. J. Cancer (1981) [Pubmed]
  3. Acute pulmonary toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride intratracheally instilled into rats. Morgan, D.L., Shines, C.J., Jeter, S.P., Wilson, R.E., Elwell, M.P., Price, H.C., Moskowitz, P.D. Environmental research. (1995) [Pubmed]
  4. Differential perturbation of erythrocyte membrane function by structurally related polycyclic aromatic hydrocarbons. Aberlin, M.E., Litman, G.W. Biochim. Biophys. Acta (1981) [Pubmed]
  5. Vapour undersaturation in primitive mid-ocean-ridge basalt and the volatile content of Earth's upper mantle. Saal, A.E., Hauri, E.H., Langmuir, C.H., Perfit, M.R. Nature (2002) [Pubmed]
  6. Inhibition of cortical collecting tubule chloride transport by organic acids. Matsuzaki, K., Stokes, J.B., Schuster, V.L. J. Clin. Invest. (1988) [Pubmed]
  7. Comparative in vitro study of the pro-apolipoprotein A-I to apolipoprotein A-I converting activity between normal and Tangier plasma. Edelstein, C., Gordon, J.I., Vergani, C.A., Catapano, A.L., Pietrini, V., Scanu, A.M. J. Clin. Invest. (1984) [Pubmed]
  8. The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. Carey, M.C., Small, D.M. J. Clin. Invest. (1978) [Pubmed]
  9. Quantitative effects of antihydrophobic agents on binding constants and solubilities in water. Breslow, R., Halfon, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. Low temperature biodegradation of airport de-icing fluids. Revitt, D.M., Worrall, P. Water Sci. Technol. (2003) [Pubmed]
  11. Intranasal corticosteroids for allergic rhinitis: how do different agents compare? Corren, J. J. Allergy Clin. Immunol. (1999) [Pubmed]
  12. A supported liquid membrane encapsulating a surfactant-lipase complex for the selective separation of organic acids. Miyako, E., Maruyama, T., Kamiya, N., Goto, M. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  13. Correlation of the solubilities of gases and vapors in methanol and ethanol with their molecular structures. Katritzky, A.R., Tatham, D.B., Maran, U. Journal of chemical information and computer sciences. (2001) [Pubmed]
  14. Contribution of monoamine oxidase(MAO) to the binding of tertiary basic drugs in isolated perfused rat lung. Yoshida, H., Okumura, K., Hori, R. Pharm. Res. (1990) [Pubmed]
  15. Influence of high biomass concentrations on alkane solubilities. Davison, B.H., Barton, J.W., Klasson, K.T., Francisco, A.B. Biotechnol. Bioeng. (2000) [Pubmed]
  16. Alteration of the Escherichia coli membrane by addition of bacteriophage T4 protein synthesized after infection. Ennis, H.L., Kievitt, K.D. J. Virol. (1977) [Pubmed]
  17. Tissue solubility of four volatile anesthetics in fresh and frozen tissue specimens from swine. Zhou, J.X., Liu, J. Am. J. Vet. Res. (2002) [Pubmed]
  18. Fermentation of soybean flour with Aspergillus usamii improves availabilities of zinc and iron in rats. Hirabayashi, M., Matsui, T., Yano, H. J. Nutr. Sci. Vitaminol. (1998) [Pubmed]
  19. The effects of fluorides and/or trace elements on the solubilities of enamel and cementum. Koray, M., Oner-Iyidogan, Y., Soyman, M., Gürdöl, F. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). (1996) [Pubmed]
  20. 7-Substituted-[1,4]dioxano[2,3-g]quinazolines as inhibitors of epidermal growth factor receptor kinase. Lee, J.Y., Park, Y.K., Seo, S.H., Yang, B.S., Park, H., Lee, Y.S. Arch. Pharm. (Weinheim) (2002) [Pubmed]
  21. Concanavalin A reduces liver collagen accumulation in murine schistosomiasis. Takahashi, S., Kobayashi, M. Hepatology (1982) [Pubmed]
  22. Physical-chemical methods for determining bilirubin solubilities in simulated bile systems. Carey, M.C. Hepatology (1984) [Pubmed]
  23. Copolymerization of normal type I collagen with three mutated type I collagens containing substitutions of cysteine at different glycine positions in the alpha 1 (I) chain. Torre-Blanco, A., Adachi, E., Romanic, A.M., Prockop, D.J. J. Biol. Chem. (1992) [Pubmed]
  24. Effects of beta 6 aromatic amino acids on polymerization and solubility of recombinant hemoglobins made in yeast. Adachi, K., Konitzer, P., Kim, J., Welch, N., Surrey, S. J. Biol. Chem. (1993) [Pubmed]
  25. Synthesis of neoglycoconjugates by transglycosylation with Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase. Demonstration of a macro-cluster effect for mannose-binding proteins. Fan, J.Q., Quesenberry, M.S., Takegawa, K., Iwahara, S., Kondo, A., Kato, I., Lee, Y.C. J. Biol. Chem. (1995) [Pubmed]
  26. Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4. Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C.L., Beyreuther, K. Eur. J. Biochem. (1991) [Pubmed]
  27. Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Tsukamoto, T., Nigam, S.K. Am. J. Physiol. (1999) [Pubmed]
  28. Analysis of a novel DNA-binding protein kinase CKII-like enzyme of Chironomus cells. Stigare, J., Buddelmeijer, N., Pigon, A., Egyházi, E. Cell. Mol. Biol. Res. (1994) [Pubmed]
  29. Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast. Nakatsukasa, K., Okada, S., Umebayashi, K., Fukuda, R., Nishikawa, S., Endo, T. J. Biol. Chem. (2004) [Pubmed]
  30. Increase of solubility of foreign proteins in Escherichia coli by coproduction of the bacterial thioredoxin. Yasukawa, T., Kanei-Ishii, C., Maekawa, T., Fujimoto, J., Yamamoto, T., Ishii, S. J. Biol. Chem. (1995) [Pubmed]
  31. Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. Armstrong, M.J., Carey, M.C. J. Lipid Res. (1987) [Pubmed]
  32. Complete mapping of crystallization pathways during cholesterol precipitation from model bile: influence of physical-chemical variables of pathophysiologic relevance and identification of a stable liquid crystalline state in cold, dilute and hydrophilic bile salt-containing systems. Wang, D.Q., Carey, M.C. J. Lipid Res. (1996) [Pubmed]
  33. Acyl chain unsaturation modulates distribution of lecithin molecular species between mixed micelles and vesicles in model bile. Implications for particle structure and metastable cholesterol solubilities. Cohen, D.E., Carey, M.C. J. Lipid Res. (1991) [Pubmed]
  34. Preparations of solid particulates of theophylline--ethylenediamine complex by a spray-drying technique. Takenaka, H., Kawashima, Y., Lin, S.Y., Ando, Y. Journal of pharmaceutical sciences. (1982) [Pubmed]
  35. Transfer of bupivacaine, lignocaine and pethidine across the rabbit placenta: influence of maternal protein binding and fetal flow. Hamshaw-Thomas, A., Rogerson, N., Reynolds, F. Placenta (1984) [Pubmed]
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