Disease relevance of Urogesic

• Renal failure in phenazopyridine overdose [1].
• Chronic severe hemolytic anemia from phenazopyridine [2].
• Phenylazopyridine (Pyridium) and acute renal failure [3].
• Phenazopyridine and aseptic meningitis [4].
• Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure [5].

Psychiatry related information on Urogesic

• METHODS: A total of 331 Chinese subjects (118 normal controls, NC, 150 with QD and 63 with mild Alzheimer's disease, AD) were assessed with the Category Verbal Fluency Test (CVFT), the AD Assessment Scale-cognitive subscale (ADAS-Cog), and digit and verbal span tests [6].

High impact information on Urogesic

• Interference by phenazopyridine with the leukocyte esterase dipstick [7].
• Phenazopyridine overdose and renal failure [8].
• Phenazopyridine-induced sulfhemoglobinemia: inadvertent rechallenge [9].
• An 18-year-old woman with no prior history of renal or hematologic dysfunction developed severe, acute methemoglobinemia after an overdose of phenazopyridine hydrochloride (Pyridium) [5].
• A 25-year-old woman taking usual doses of phenazopyridine developed her third clinically significant episode of cyanosis [10].

Chemical compound and disease context of Urogesic

• Before the diagnosis of an "inducible" porphyria is made, a positive Hoesch test requires that indoles, indoleacetic acid, methyldopa, end-stage alcoholic malnutrition, and phenazopyridine HCl be excluded, to avoid misinterpretation [11].
• It is suggested that the need for repeated doses of methylene blue in this case was not only related to the large dose of phenazopyridine, but also its metabolites (i.e., aniline), which have the potential to produce methemoglobinemia [12].
• In patients having prostatitis, response was satisfactory in 66 per cent treated with flavoxate and 31 per cent treated with phenazopyridine [13].
• The relationship between a pentagastrin-stimulated gastric luminal acid production test (Gastrotest) and enteral feeding-related gastrointestinal complications in critically ill patients [14].
• Although the differential diagnosis for renal failure and hemolytic anemia is extensive, scleral icterus, normal bilirubin, and orange-colored urine raised the suspicion of phenazopyridine use [15].

Biological context of Urogesic

• Capillary electrophoretic determination of apoptosis of rat cerebellar granule cells induced by 1-methyl-4-phenyl pyridium ion [16].
• Ciprofloxacin bioavailability is enhanced by oral co-administration with phenazopyridine: a pharmacokinetic study in a Mexican population [17].
• The chemoselective acetylation of phenazopyridine (2) and its influence on the polarization of the azo nitrogen atoms were evidenced by the (15)N NMR spectra [18].
• To date, the most valuable bone markers are serum osteocalcin, bone-specific alkaline phosphatase, and the N-terminal propeptide of type 1 procollagen for bone formation and urinary measurements of the phenazopyridine crosslinks and related telopeptides for bone resorption [19].
• Ten patients with uncomplicated pregnancies undergoing elective amniocentesis for obstetric indications received an oral dose of 400 mg of phenazopyridine hydrochloride 4 hours prior to the procedure [20].

Anatomical context of Urogesic

• Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase [10].
• Generation of superoxide radical and hydrogen peroxide by 2,3,6-triaminopyridine, a metabolite of the urinary tract analgesic phenazopyridine [21].
• Adding pyridium did not improve the specificity of the test, despite instructing subjects to milk the urethra and blot before applying the pad [22].
• Before feeding, the change in the pH of gastric juice was measured in response to a subcutaneous injection of pentagastrin (Gastrotest) [14].
• Lower dosages of phenazopyridine (10 and 20 mg/kg/day) for longer periods of administration to 2 other clinically normal cats did not result in illness or anemia; however, the number and size of Heinz bodies and blood methemoglobin content were increased [23].

Associations of Urogesic with other chemical compounds

• Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical bases and their hydrochloride salts. I: Phenazopyridine [24].
• Urinary tract disorders. Clinical comparison of flavoxate and phenazopyridine [13].
• The equilibrium solubilities of three drugs (phenazopyridine, propranolol and methimazole) were determined at temperatures ranging from 308 to 348 K and pressures from 122 to 355 bar in supercritical CO2 by a simple and reliable static method [25].

Gene context of Urogesic

• Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency [26].
• This study examines whether consumers inappropriately use and substitute a recently widely distributed OTC urinary analgesic, phenazopyridine, for provider care [27].
• The metabolism of the urinary tract analgesic phenazopyridine [2,6-diamino-3-(phenylazo)pyridine; PAP] was studied in the urine of humans, rats, mice, and guinea pigs [28].
• After liquid-liquid extraction, the phenazopyridine in the plasma was analyzed on a C18 column under SIM mode [29].
• A 16-month-old male presented with an overdose of Pyridium Plus--a combination anticholinergic, azo dye, and barbiturate--resulting in seizures, coma, and methemoglobinemia [30].

Analytical, diagnostic and therapeutic context of Urogesic

• The diagnostic studies for vaginal ureteral ectopia include excretory urography, radionuclide scanning, ultrasonography and administration of oral phenazopyridine in conjunction with careful vaginoscopic examination [31].
• DESIGN/SETTING: We conducted a cross-sectional survey of a stratified cluster random sample of OTC phenazopyridine purchasers (N = 434) in 31 Los Angeles retail pharmacies over 5 months [27].
• The 9 patients (47%) who were Gastrotest responders before starting enteral feeding exhibited a significantly larger volume ratio (P = 0.01) and fewer GICs (1 [11%] versus 8 [80%]; P < 0.05) [14].
• Severe illness developed after the oral administration of several drugs, including large doses of phenazopyridine (100 mg TID for 4 days) to a cat with dysuria and hematuria [23].
• The method was used to quantitative analysis of phenazopyridine in human plasma by HPLC/UV [32].

References