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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.[1]

References

  1. Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits. Blank, T., Nijholt, I., Kye, M.J., Radulovic, J., Spiess, J. Nat. Neurosci. (2003) [Pubmed]
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