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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The CCT chaperonin promotes activation of the anaphase- promoting complex through the generation of functional Cdc20.

The WD repeat protein Cdc20 is essential for progression through mitosis because it is required to activate ubiquitin ligation by the anaphase-promoting complex (APC/C). Here we show in yeast that Cdc20 binds to the CCT chaperonin, which is known as a folding machine for actin and tubulin. The CCT is required for Cdc20's ability to bind and activate the APC/C. In vivo, CCT is essential for Cdc20-dependent cell cycle events such as sister chromatid separation and exit from mitosis. The chaperonin is also required for the function of the Cdc20-related protein Cdh1, which activates the APC/C during G1. We propose that folding of the Cdc20 family of APC/C activators is an essential and evolutionary conserved function of the CCT chaperonin.[1]

References

  1. The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20. Camasses, A., Bogdanova, A., Shevchenko, A., Zachariae, W. Mol. Cell (2003) [Pubmed]
 
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