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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

Decreased levels of beta-amyloid peptide 1-42 (Abeta1-42) in cerebrospinal fluid (CSF) are a characteristic feature of Alzheimer's disease (AD) but recently were also observed in Creutzfeldt-Jakob disease (CJD). We analyzed the CSF of patients with CJD, and AD and nondemented controls using a quantitative urea-based Abeta sodium dodecyl sulfate polyacrylamide gel electrophoresis immunoblot. Like in AD and nondemented controls, we found a highly conserved pattern of carboxyterminally truncated Abeta1-37/38/39 in addition to Abeta1-40/42 also in CJD patients. By the introduction of the ratio Abeta1-39 to Abeta1-42, CJD and AD can effectively be differentiated. We conclude that the immunoblot shows disease-specific CSF Abeta peptide patterns in CJD and AD and suppose that measurement of the Abeta peptide pattern seems to be a promising diagnostic tool in the differential diagnosis of dementias.[1]


  1. Beta-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. Wiltfang, J., Esselmann, H., Smirnov, A., Bibl, M., Cepek, L., Steinacker, P., Mollenhauer, B., Buerger, K., Hampel, H., Paul, S., Neumann, M., Maler, M., Zerr, I., Kornhuber, J., Kretzschmar, H.A., Poser, S., Otto, M. Ann. Neurol. (2003) [Pubmed]
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