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Chemical Compound Review

Sulfotex wa     1-sulfooxydodecane

Synonyms: Trepenol WA, Swascol 3L, Swascol 4L, Sulfopon WA2, Sulfopon WA3, ...
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Disease relevance of Sodium dodecyl sulfate

  • SDS, however, up-regulated CD86 expression to 125-138% of control in 2/4 preparations when tested at concentrations which induced similar toxicity [1].
  • E. coli was quantified by the most probable number, using lauryl sulphate tryptose broth with 4-methylumbelliferyl-beta-D-glucuronide [2].
  • Chlorhexidine diacetate (CHA) was rather more sporicidal at 20 degrees C to urea-dithreitol-sodium lauryl sulphate (UDS)-treated spores of Bacillus subtilis NCTC 8236 than to urea-dithiothreitol (UDT)-treated or normal (untreated) spores [3].

High impact information on Sodium dodecyl sulfate

  • Sodium dodecyl sulfate (SDS) gel comparisons of the complexes formed with M1-type alpha 1AT and Z-type alpha 1AT with elastase demonstrated the Z alpha 1AT-elastase complexes were less stable than the M1 alpha 1AT-elastase complexes, thus releasing some of the enzyme to continue to function as a protease [4].
  • Brain PrP(C) treated with acidic pH/GdnHCl acquired partial PK resistance upon further treatment with low concentrations of sodium dodecyl sulfate (SDS) [5].
  • Most of the increase was due to alpha-synuclein in SDS fractions [6].
  • Denaturing mono-N-carbethoxy lysozyme with 2-ME and 8 M urea (55 degrees C) or 1% SDS (100 degrees C) essentially abolished its circular dichroism difference spectrum in the 240-260 nm region without any decarbethoxylation [7].
  • The purified catalytic subunit also exhibited a Ca2+-dependent shift in its mobility on SDS gels.(ABSTRACT TRUNCATED AT 400 WORDS)[8]

Biological context of Sodium dodecyl sulfate

  • Time-course experiments showed that increased PR phosphorylation that results from hormone addition is a multistep process and involves a rapid increase into total 32P labeling that takes place before the more slowly occurring phosphorylation(s) responsible for the change in electrophoretic mobility of PR on SDS-gels [9].
  • The dimorphism is therefore likely to influence antigen presentation and forms the molecular basis for the observed differences in stability of Val86- and Gly86-containing DR dimers in the presence of SDS [10].
  • Hence, the receptor monomer was also dissociated into subunits of Mr 85K and 38K by reduction of -S-S-bonds with 50 mM DTT in 2% SDS and alkylation of sulfhydryl groups in the presence of 100 mM N-ethyl-maleimide [11].
  • Major histocompatibility complex class II molecules exist in two forms, which can be distinguished on the basis of their stability in sodium dodecyl sulfate (SDS) as SDS-stable and SDS-unstable alpha beta dimers [10].
  • First, the acylation of PBP 9 by these beta-lactams paralleled the inhibition of DD-carboxypeptidase and the inhibition of SDS-insoluble peptidoglycan synthesis [12].

Anatomical context of Sodium dodecyl sulfate

  • Here, we present the application of the SDS-digested freeze-fracture replica labeling (SDS-FRL) technique to the transmembrane distribution of a major membrane phospholipid, phosphatidylcholine (PC), in various cell and intracellular membranes [13].
  • Sodium dodecyl sulfate (SDS) gel electrophoresis of membrane proteins showed a progressive loss of the cytoskeleton proteins and formation of low molecular weight bands and protein aggregates, with an increment of the intensity of the Hb band [14].
  • To study whether CTX assembles into oligomer on target membranes, we solubilized membrane-bound toxin with 1% sodium dodecyl sulfate (SDS) at 25 degrees C and analyzed its molecular size using SDS-polyacrylamide gel electrophoresis and immunoblot analysis [15].
  • When insulin was injected into the distal jejunum/proximal ileum segment of the rat, 5 mM SDS greatly enhanced its pharmacological availability, from a negligible value to 2.8% [16].
  • Surface active substances (lauryl sulphate and cetyl 3-ammonium bromide) give a lubricating ability similar to that of synovial fluid [17].

Associations of Sodium dodecyl sulfate with other chemical compounds


Gene context of Sodium dodecyl sulfate

  • Interactions of basic residues of SP-B with anionic lipid headgroups are known to have an impact on function, and these studies demonstrate structural ramifications of such interactions via the differences observed between the peptide structures determined in HFIP and SDS [21].
  • Porcine C3 also resembles the human analogue by forming dimers after being subjected to methylamine and dilute lauryl sulphate: Mr = 404,000 and R = 7.9 nm [22].
  • Rabbit antiserum prepared against the sodium dodecyl sulfate (SDS) denaturated bovine E2 subunit recognized the inner E2 core, and the first hinge region of the E2 chain, but failed to react with the lipoyl-bearing domain as determined by Western blot analysis [23].
  • When first cross-linked with dimethyl suberimidate and then submitted to electrophoresis in SDS, citrate synthase showed six bands, in widely different amounts, whose apparent molecular weights were almost integral multiples of 47,000 g/mol [19].
  • Online preconcentration of thyrotropin-releasing hormone (TRH) by SDS-modified reversed phase column for microbore and capillary high-performance liquid chromatography (HPLC) [24].

Analytical, diagnostic and therapeutic context of Sodium dodecyl sulfate


  1. Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen. Hulette, B.C., Ryan, C.A., Gildea, L.A., Gerberick, G.F. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  2. Recovery of Escherichia coli in fresh water fish, Jenynsia multidentata and Bryconamericus iheringi. Guzmán, M.C., Bistoni, M.d.e. .L., Tamagnini, L.M., González, R.D. Water Res. (2004) [Pubmed]
  3. Mechanism of resistance of Bacillus subtilis spores to chlorhexidine. Shaker, L.A., Furr, J.R., Russell, A.D. J. Appl. Bacteriol. (1988) [Pubmed]
  4. Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase. Ogushi, F., Fells, G.A., Hubbard, R.C., Straus, S.D., Crystal, R.G. J. Clin. Invest. (1987) [Pubmed]
  5. Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form. Zou, W.Q., Cashman, N.R. J. Biol. Chem. (2002) [Pubmed]
  6. Widespread alterations of alpha-synuclein in multiple system atrophy. Dickson, D.W., Liu, W., Hardy, J., Farrer, M., Mehta, N., Uitti, R., Mark, M., Zimmerman, T., Golbe, L., Sage, J., Sima, A., D'Amato, C., Albin, R., Gilman, S., Yen, S.H. Am. J. Pathol. (1999) [Pubmed]
  7. Circular dichroism studies of diethyl pyrocarbonate-modified histidine in hen egg white lysozyme. Li, C., Moore, D.S., Rosenberg, R.C. J. Biol. Chem. (1993) [Pubmed]
  8. The interaction of Ca2+ with the calmodulin-sensitive adenylate cyclase from Bordetella pertussis. Masure, H.R., Oldenburg, D.J., Donovan, M.G., Shattuck, R.L., Storm, D.R. J. Biol. Chem. (1988) [Pubmed]
  9. Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors. Beck, C.A., Weigel, N.L., Edwards, D.P. Mol. Endocrinol. (1992) [Pubmed]
  10. HLA-DR beta chain residue 86 controls DR alpha beta dimer stability. Verreck, F.A., Termijtelen, A., Koning, F. Eur. J. Immunol. (1993) [Pubmed]
  11. Subunits of luteinizing hormone-human chorionic gonadotropin receptor from bovine corpora lutea. Saxena, B.B., Dattatreyamurty, B., Ota, H., Milkov, V., Rathnam, P. Biochemistry (1986) [Pubmed]
  12. In vivo target of benzylpenicillin in Gaffkya homari. Wrezel, P.W., Ellis, L.F., Neuhaus, F.C. Antimicrob. Agents Chemother. (1986) [Pubmed]
  13. Transmembrane phospholipid distribution revealed by freeze-fracture replica labeling. Fujimoto, K., Umeda, M., Fujimoto, T. J. Cell. Sci. (1996) [Pubmed]
  14. Melatonin protects human red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity. Tesoriere, L., D'Arpa, D., Conti, S., Giaccone, V., Pintaudi, A.M., Livrea, M.A. J. Pineal Res. (1999) [Pubmed]
  15. Mechanism of the cytolytic action of Pseudomonas aeruginosa cytotoxin: oligomerization of the cytotoxin on target membranes. Ohnishi, M., Hayashi, T., Tomita, T., Terawaki, Y. FEBS Lett. (1994) [Pubmed]
  16. Differential effects of anionic, cationic, nonionic, and physiologic surfactants on the dissociation, alpha-chymotryptic degradation, and enteral absorption of insulin hexamers. Shao, Z., Li, Y., Krishnamoorthy, R., Chermak, T., Mitra, A.K. Pharm. Res. (1993) [Pubmed]
  17. Lubrication and cartilage. Wright, V., Dowson, D. J. Anat. (1976) [Pubmed]
  18. Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity. Riesner, D., Kellings, K., Post, K., Wille, H., Serban, H., Groth, D., Baldwin, M.A., Prusiner, S.B. J. Virol. (1996) [Pubmed]
  19. The quaternary structure of citrate synthase from Escherichia coli K12. Tong, E.K., Duckworth, H.W. Biochemistry (1975) [Pubmed]
  20. Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosphorylation, and processing. Wei, L.L., Sheridan, P.L., Krett, N.L., Francis, M.D., Toft, D.O., Edwards, D.P., Horwitz, K.B. Biochemistry (1987) [Pubmed]
  21. NMR structures of the C-terminal segment of surfactant protein B in detergent micelles and hexafluoro-2-propanol. Booth, V., Waring, A.J., Walther, F.J., Keough, K.M. Biochemistry (2004) [Pubmed]
  22. Correlation between the human and porcine complement system: a small-angle scattering study of cross immunity and methylamine-induced conformational changes of porcine C3 and C4 proteins. Osterberg, R., Malmensten, B., Boive, T., Nilsson, U., Stigbrand, T., Mortensen, K. Mol. Immunol. (1991) [Pubmed]
  23. Conservation of primary structure in the lipoyl-bearing and dihydrolipoyl dehydrogenase binding domains of mammalian branched-chain alpha-keto acid dehydrogenase complex: molecular cloning of human and bovine transacylase (E2) cDNAs. Lau, K.S., Griffin, T.A., Hu, C.W., Chuang, D.T. Biochemistry (1988) [Pubmed]
  24. Online preconcentration of thyrotropin-releasing hormone (TRH) by SDS-modified reversed phase column for microbore and capillary high-performance liquid chromatography (HPLC). Meng, R., Xia, W., Sandberg, M., Stephens, R., Weber, S.G. Journal of chromatography. A. (2005) [Pubmed]
  25. Isolation of alpha 1-protease inhibitor from human normal and malignant ovarian tissue. Bagdasarian, A., Wheeler, J., Stewart, G.J., Ahmed, S.S., Colman, R.W. J. Clin. Invest. (1981) [Pubmed]
  26. Fibrillogenic and Non-fibrillogenic Ensembles of SDS-bound Human alpha-Synuclein. Ahmad, M.F., Ramakrishna, T., Raman, B., Rao, C.h.M. J. Mol. Biol. (2006) [Pubmed]
  27. Investigation of micelles and anionic cyclodextrins as pseudostationary phases for the capillary electrophoresis separation of oligosaccharides derivatized with 2-amino-benzamide. Tran, N.T., Taverna, M., Deschamps, F.S., Morin, P., Ferrier, D. Electrophoresis (1998) [Pubmed]
  28. Trypsin activity assay in substrate-specific one- and two-dimensional gels: a powerful method to separate and characterize novel proteases in active form in biological samples. Zhao, Z., Russell, P.J. Electrophoresis (2003) [Pubmed]
  29. Development of HPLC conditions for valid determination of hydrolysis products of cisplatin. El-Khateeb, M., Appleton, T.G., Charles, B.G., Gahan, L.R. Journal of pharmaceutical sciences. (1999) [Pubmed]
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