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Hentsch, A. et al.

Hentsch, Aschauer, Balzer, Brossmann, Busch, Davis, Douek, Ebner, van Engelshoven, Gregor, Kersting, Knüsel, Leen, Leiner, Loewe, McPherson, Reimer, Schäfer, Taupitz, Thurnher, Tombach, Wegener, Weishaupt, Meaney,

Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography.

The purpose of this study was to compare moving-table three-dimensional contrast-enhanced magnetic resonance angiography (CE MRA), using 1.0-mol gadobutrol, with intra-arterial digital subtraction angiography (i.a. DSA) for evaluation of pelvic and peripheral arteries in patients with peripheral arterial occlusive disease. A total of 203 patients were examined in a prospective, multi-centre study at 1.0/1.5 T. Ten vessel segments of one leg were evaluated on-site and by three independent blinded reviewers off-site. One hundred eighty-two patients were evaluable in blinded reading. For pelvis and thigh, there was statistically significant diagnostic agreement between CE MRA and i.a. DSA on-site (94%) and off-site (86-88%). Overall, for detection of clinically significant stenoses, 93% sensitivity and 90% specificity were achieved in on-site evaluation, with 71-76 and 87-93% off-site; for detection of occlusion, sensitivity and specificity on-site were 91 and 97%, with 75-82 and 94-98% off-site. Evaluation was more sensitive on-site than off-site for detection of stenoses and occlusion, whereas specificity was similar. The CE MRA with 1.0-mol gadobutrol gave results comparable to those of i.a. DSA for the larger arteries of pelvis and thigh. Results for calf arteries were compromised by spatial resolution and technical limitations.[1]

References

Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography. Hentsch, A., Aschauer, M.A., Balzer, J.O., Brossmann, J., Busch, H.P., Davis, K., Douek, P., Ebner, F., van Engelshoven, J.M., Gregor, M., Kersting, C., Knüsel, P.R., Leen, E., Leiner, T., Loewe, C., McPherson, S., Reimer, P., Schäfer, F.K., Taupitz, M., Thurnher, S.A., Tombach, B., Wegener, R., Weishaupt, D., Meaney, J.F. European radiology. (2003) [Pubmed]

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