The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Constriction, Pathologic

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Constriction, Pathologic


Psychiatry related information on Constriction, Pathologic


High impact information on Constriction, Pathologic

  • Among 138 patients who had unilateral or bilateral renal-artery stenosis of more than 50 percent of the luminal diameter and who underwent renal angioplasty or surgery, the procedure was technically successful in 131 (95 percent) [8].
  • Creatinine clearance and 24-hour ambulatory blood pressure were measured before renal-artery stenosis was corrected; 3, 6, and 12 months after the procedure; and yearly thereafter [8].
  • METHODS: We assessed the systemic, pulmonary, and coronary hemodynamic effects of oral sildenafil (100 mg) in 14 men (mean [+/-SD] age, 61+/-11 years) with severe stenosis of at least one coronary artery (stenosis of >70 percent of the vessel diameter) who were scheduled to undergo percutaneous coronary revascularization [9].
  • Among 1604 patients with stenosis of less than 60 percent of the luminal diameter, the risk of a first stroke was 8.0 percent (1.6 percent annually), as compared with 16.2 percent (3.2 percent annually) among 216 patients with 60 to 99 percent stenosis [10].
  • Some patients also have pulmonic stenosis, persistence of a left-sided superior vena cava or transposition of the great arteries [11].

Chemical compound and disease context of Constriction, Pathologic

  • The primary end point was angiographic evidence of restenosis (defined as stenosis of more than 50 percent of the luminal diameter) at six months [12].
  • Despite a 42 percent reduction in the serum level of low-density lipoprotein cholesterol in the lovastatin group, after six months of treatment the amount of stenosis seen in the second angiogram was 46 +/- 20 percent in the placebo group, as compared with 44 +/- 21 percent in the lovastatin group (P = 0.50) [13].
  • Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis [14].
  • After streptokinase infusion, intracoronary administration of isosorbide dinitrate was followed by dilatation of the infarct-related stenosis from a mean value (+/- SD) of 1.12 +/- 0.3 mm (58.1 +/- 12.1 percent) to 1.33 +/- 0.4 mm (51.6 +/- 12.9 percent; P = 0.004) [15].
  • In contrast, all eight of the arteries with advanced stenoses showed dose-dependent constriction, from 1.05 +/- 0.05 to 0.32 +/- 0.16 mm at the highest concentration of acetylcholine (P less than 0.01), with temporary occlusion in five [16].

Biological context of Constriction, Pathologic


Anatomical context of Constriction, Pathologic


Gene context of Constriction, Pathologic


Analytical, diagnostic and therapeutic context of Constriction, Pathologic

  • Significant restenosis, as indicated by a reduction of 0.72 mm in the minimal luminal diameter or by an increase in the percentage of stenosis to greater than or equal to 50 percent, occurred in 32 percent and 14 percent of patent stents, respectively [32].
  • Selective coronary arteriography performed on a 41-year-old woman with angina pectoris demonstrated proximal stenosis of the right and left main coronary arteries that was unaffected by nitrate therapy [33].
  • In the apheresis group, the number of patients with hemodynamically significant stenoses in the aortotibial tract decreased from 9 to 7; in the simvastatin-only group, the number increased from 6 to 13 (P = 0.002) [34].
  • Slow regional clearance of myocardial thallium-201 in the absence of perfusion defect: contribution to detection of individual coronary artery stenoses and mechanism for occurrence [35].
  • The angiographic severity of stenosis was compared with the transstenotic pressure gradient measured with the dilation catheter during angioplasty and with the results of exercise thallium scintigraphy [36].


  1. The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis. Dutch Renal Artery Stenosis Intervention Cooperative Study Group. van Jaarsveld, B.C., Krijnen, P., Pieterman, H., Derkx, F.H., Deinum, J., Postma, C.T., Dees, A., Woittiez, A.J., Bartelink, A.K., Man in 't Veld, A.J., Schalekamp, M.A. N. Engl. J. Med. (2000) [Pubmed]
  2. Relation between myocardial blood flow and the severity of coronary-artery stenosis. Uren, N.G., Melin, J.A., De Bruyne, B., Wijns, W., Baudhuin, T., Camici, P.G. N. Engl. J. Med. (1994) [Pubmed]
  3. Prognosis after transient monocular blindness associated with carotid-artery stenosis. Benavente, O., Eliasziw, M., Streifler, J.Y., Fox, A.J., Barnett, H.J., Meldrum, H. N. Engl. J. Med. (2001) [Pubmed]
  4. Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney. Hricik, D.E., Browning, P.J., Kopelman, R., Goorno, W.E., Madias, N.E., Dzau, V.J. N. Engl. J. Med. (1983) [Pubmed]
  5. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Tartaglia, M., Mehler, E.L., Goldberg, R., Zampino, G., Brunner, H.G., Kremer, H., van der Burgt, I., Crosby, A.H., Ion, A., Jeffery, S., Kalidas, K., Patton, M.A., Kucherlapati, R.S., Gelb, B.D. Nat. Genet. (2001) [Pubmed]
  6. Distinct craniofacial-skeletal-dermatological dysplasia in a patient with W290C mutation in FGFR2. Shotelersuk, V., Ittiwut, C., Srivuthana, S., Mahatumarat, C., Lerdlum, S., Wacharasindhu, S. Am. J. Med. Genet. (2002) [Pubmed]
  7. Diabetes mellitus and arteriographically-documented coronary artery disease. Freedman, D.S., Gruchow, H.W., Bamrah, V.S., Anderson, A.J., Barboriak, J.J. Journal of clinical epidemiology. (1988) [Pubmed]
  8. Use of Doppler ultrasonography to predict the outcome of therapy for renal-artery stenosis. Radermacher, J., Chavan, A., Bleck, J., Vitzthum, A., Stoess, B., Gebel, M.J., Galanski, M., Koch, K.M., Haller, H. N. Engl. J. Med. (2001) [Pubmed]
  9. Hemodynamic effects of sildenafil in men with severe coronary artery disease. Herrmann, H.C., Chang, G., Klugherz, B.D., Mahoney, P.D. N. Engl. J. Med. (2000) [Pubmed]
  10. The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Inzitari, D., Eliasziw, M., Gates, P., Sharpe, B.L., Chan, R.K., Meldrum, H.E., Barnett, H.J. N. Engl. J. Med. (2000) [Pubmed]
  11. A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Svensson, E.C., Huggins, G.S., Lin, H., Clendenin, C., Jiang, F., Tufts, R., Dardik, F.B., Leiden, J.M. Nat. Genet. (2000) [Pubmed]
  12. Coronary-artery stenting compared with balloon angioplasty for restenosis after initial balloon angioplasty. Restenosis Stent Study Group. Erbel, R., Haude, M., Höpp, H.W., Franzen, D., Rupprecht, H.J., Heublein, B., Fischer, K., de Jaegere, P., Serruys, P., Rutsch, W., Probst, P. N. Engl. J. Med. (1998) [Pubmed]
  13. Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin Restenosis Trial Study Group. Weintraub, W.S., Boccuzzi, S.J., Klein, J.L., Kosinski, A.S., King, S.B., Ivanhoe, R., Cedarholm, J.C., Stillabower, M.E., Talley, J.D., DeMaio, S.J. N. Engl. J. Med. (1994) [Pubmed]
  14. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. Selhub, J., Jacques, P.F., Bostom, A.G., D'Agostino, R.B., Wilson, P.W., Belanger, A.J., O'Leary, D.H., Wolf, P.A., Schaefer, E.J., Rosenberg, I.H. N. Engl. J. Med. (1995) [Pubmed]
  15. Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. Hackett, D., Davies, G., Chierchia, S., Maseri, A. N. Engl. J. Med. (1987) [Pubmed]
  16. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. Ludmer, P.L., Selwyn, A.P., Shook, T.L., Wayne, R.R., Mudge, G.H., Alexander, R.W., Ganz, P. N. Engl. J. Med. (1986) [Pubmed]
  17. Myocardial kinetics of thallium-201 after dipyridamole infusion in normal canine myocardium and in myocardium distal to a stenosis. Okada, R.D., Leppo, J.A., Boucher, C.A., Pohost, G.M. J. Clin. Invest. (1982) [Pubmed]
  18. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Tsai, M.H., Iwakiri, Y., Cadelina, G., Sessa, W.C., Groszmann, R.J. Gastroenterology (2003) [Pubmed]
  19. Multifocal stenosing ulcerations of the small intestine revealing vasculitis associated with C2 deficiency. Perlemuter, G., Chaussade, S., Soubrane, O., Degoy, A., Louvel, A., Barbet, P., Legman, P., Kahan, A., Weiss, L., Couturier, D. Gastroenterology (1996) [Pubmed]
  20. Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study. Rustin, P., von Kleist-Retzow, J.C., Chantrel-Groussard, K., Sidi, D., Munnich, A., Rötig, A. Lancet (1999) [Pubmed]
  21. Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1. Ayadi, A., Zheng, H., Sobieszczuk, P., Buchwalter, G., Moerman, P., Alitalo, K., Wasylyk, B. EMBO J. (2001) [Pubmed]
  22. A prospective randomized clinical trial of intracoronary streptokinase versus coronary angioplasty for acute myocardial infarction. O'Neill, W., Timmis, G.C., Bourdillon, P.D., Lai, P., Ganghadarhan, V., Walton, J., Ramos, R., Laufer, N., Gordon, S., Schork, M.A. N. Engl. J. Med. (1986) [Pubmed]
  23. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M., Hui, C.C. Nat. Genet. (1998) [Pubmed]
  24. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. Gruber, P.J., Kubalak, S.W., Pexieder, T., Sucov, H.M., Evans, R.M., Chien, K.R. J. Clin. Invest. (1996) [Pubmed]
  25. Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract. Veyradier, A., Balian, A., Wolf, M., Giraud, V., Montembault, S., Obert, B., Dagher, I., Chaput, J.C., Meyer, D., Naveau, S. Gastroenterology (2001) [Pubmed]
  26. Methylene blue and atresia or stenosis of ileum and jejunum. EUROCAT Working Group. Dolk, H. Lancet (1991) [Pubmed]
  27. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Tartaglia, M., Kalidas, K., Shaw, A., Song, X., Musat, D.L., van der Burgt, I., Brunner, H.G., Bertola, D.R., Crosby, A., Ion, A., Kucherlapati, R.S., Jeffery, S., Patton, M.A., Gelb, B.D. Am. J. Hum. Genet. (2002) [Pubmed]
  28. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Erlich, P.M., Lunetta, K.L., Cupples, L.A., Huyck, M., Green, R.C., Baldwin, C.T., Farrer, L.A. Hum. Mol. Genet. (2006) [Pubmed]
  29. Hedgehog signals regulate multiple aspects of gastrointestinal development. Ramalho-Santos, M., Melton, D.A., McMahon, A.P. Development (2000) [Pubmed]
  30. Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy. Nikkari, S.T., Geary, R.L., Hatsukami, T., Ferguson, M., Forough, R., Alpers, C.E., Clowes, A.W. Am. J. Pathol. (1996) [Pubmed]
  31. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. Matsuda, M., Shimomura, I., Sata, M., Arita, Y., Nishida, M., Maeda, N., Kumada, M., Okamoto, Y., Nagaretani, H., Nishizawa, H., Kishida, K., Komuro, R., Ouchi, N., Kihara, S., Nagai, R., Funahashi, T., Matsuzawa, Y. J. Biol. Chem. (2002) [Pubmed]
  32. Angiographic follow-up after placement of a self-expanding coronary-artery stent. Serruys, P.W., Strauss, B.H., Beatt, K.J., Bertrand, M.E., Puel, J., Rickards, A.F., Meier, B., Goy, J.J., Vogt, P., Kappenberger, L. N. Engl. J. Med. (1991) [Pubmed]
  33. Alpha-adrenoceptor-mediated coronary artery spasm. Levene, D.L., Freeman, M.R. JAMA (1976) [Pubmed]
  34. Effect of apheresis of low-density lipoprotein on peripheral vascular disease in hypercholesterolemic patients with coronary artery disease. Kroon, A.A., van Asten, W.N., Stalenhoef, A.F. Ann. Intern. Med. (1996) [Pubmed]
  35. Slow regional clearance of myocardial thallium-201 in the absence of perfusion defect: contribution to detection of individual coronary artery stenoses and mechanism for occurrence. Abdulla, A., Maddahi, J., Garcia, E., Rozanski, A., Swan, H.J., Berman, D.S. Circulation (1985) [Pubmed]
  36. Quantitative angiography of the left anterior descending coronary artery: correlations with pressure gradient and results of exercise thallium scintigraphy. Wijns, W., Serruys, P.W., Reiber, J.H., van den Brand, M., Simoons, M.L., Kooijman, C.J., Balakumaran, K., Hugenholtz, P.G. Circulation (1985) [Pubmed]
WikiGenes - Universities