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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Old livers--C/EBPalpha meets new partners.

The aging liver loses the ability to proliferate after partial hepatic resections. We have recently found that, in liver, aging switches C/EBPalpha from inhibition of Cdks to repression of E2F, the pathway that normally operates in adipose tissues. This switch causes a loss of proliferative response in old livers because of an inability to induce E2F target genes after partial hepatectomy.[1]

References

  1. Old livers--C/EBPalpha meets new partners. Timchenko, N.A. Cell Cycle (2003) [Pubmed]
 
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