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Disease relevance of Hepatectomy


Psychiatry related information on Hepatectomy


High impact information on Hepatectomy


Chemical compound and disease context of Hepatectomy


Biological context of Hepatectomy


Anatomical context of Hepatectomy


Associations of Hepatectomy with chemical compounds

  • The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury [25].
  • A decrease in the activity of the enzyme cytidine 3',5'-monophosphate (cyclic CMP) phosphodiesterase was noted in the regenerating liver of young rats as early as 8 hours after partial hepatectomy, with a maximum decrease occurring 12 hours after the surgery [26].
  • C3- or C5-deficient mice exhibited high mortality, parenchymal damage, and impaired liver regeneration after partial hepatectomy [27].
  • The effect of partial hepatectomy (PH) on alteration of liver foci induced by N-nitrosodiethylamine (DENA) was studied in inbred F344 male rats [28].
  • In rats fed for 16 weeks with ethanol, hepatocellular proliferation induced by partial hepatectomy was greatly impaired [29].

Gene context of Hepatectomy


Analytical, diagnostic and therapeutic context of Hepatectomy


  1. Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes. Strain, A.J., Ismail, T., Tsubouchi, H., Arakaki, N., Hishida, T., Kitamura, N., Daikuhara, Y., McMaster, P. J. Clin. Invest. (1991) [Pubmed]
  2. Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver. Hayes, M.A., Roberts, E., Safe, S.H., Farber, E., Cameron, R.G. J. Natl. Cancer Inst. (1986) [Pubmed]
  3. Energy metabolism and regeneration in transgenic mouse liver expressing creatine kinase after major hepatectomy. Satoh, S., Tanaka, A., Hatano, E., Inomoto, T., Iwata, S., Kitai, T., Shinohara, H., Tsunekawa, S., Chance, B., Yamaoka, Y. Gastroenterology (1996) [Pubmed]
  4. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. Caulin, C., Ware, C.F., Magin, T.M., Oshima, R.G. J. Cell Biol. (2000) [Pubmed]
  5. Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. Rai, R.M., Lee, F.Y., Rosen, A., Yang, S.Q., Lin, H.Z., Koteish, A., Liew, F.Y., Zaragoza, C., Lowenstein, C., Diehl, A.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Effect of acute ethanol consumption on hepatic lysosomal enzymes and calcium concentration during rat liver regeneration. Suleiman, S.A., Kadoumi, O.F. Ital. J. Biochem. (1990) [Pubmed]
  7. Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Iakova, P., Awad, S.S., Timchenko, N.A. Cell (2003) [Pubmed]
  8. Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma. Fan, S.T., Lo, C.M., Lai, E.C., Chu, K.M., Liu, C.L., Wong, J. N. Engl. J. Med. (1994) [Pubmed]
  9. Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Palmiter, R.D., Chen, H.Y., Brinster, R.L. Cell (1982) [Pubmed]
  10. Fas engagement accelerates liver regeneration after partial hepatectomy. Desbarats, J., Newell, M.K. Nat. Med. (2000) [Pubmed]
  11. Increased erythropoietin production in anephric rats with hyperplasia of the reticuloendothelial system induced by colloidal carbon or zymosan. Peschle, C., Marone, G., Genovese, A., Rappaport, I.A., Condorelli, M. Blood (1976) [Pubmed]
  12. Expression of the c-raf protooncogene, gamma-glutamyltranspeptidase, and gap junction protein in rat liver neoplasms. Beer, D.G., Neveu, M.J., Paul, D.L., Rapp, U.R., Pitot, H.C. Cancer Res. (1988) [Pubmed]
  13. Hepatic fibrosis as a predictor of hepatic regenerative activity after partial hepatectomy in the rat. MacIntosh, E.L., Gauthier, T., Pettigrew, N.M., Minuk, G.Y. Hepatology (1993) [Pubmed]
  14. Depressed liver regeneration after partial hepatectomy of germ-free, athymic and lipopolysaccharide-resistant mice. Cornell, R.P., Liljequist, B.L., Bartizal, K.F. Hepatology (1990) [Pubmed]
  15. Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy. Malik, R., Mellor, N., Selden, C., Hodgson, H. Hepatology (2003) [Pubmed]
  16. C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Makino, R., Hayashi, K., Sugimura, T. Nature (1984) [Pubmed]
  17. Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth. Greenbaum, L.E., Cressman, D.E., Haber, B.A., Taub, R. J. Clin. Invest. (1995) [Pubmed]
  18. Amphiregulin: an early trigger of liver regeneration in mice. Berasain, C., García-Trevijano, E.R., Castillo, J., Erroba, E., Lee, D.C., Prieto, J., Avila, M.A. Gastroenterology (2005) [Pubmed]
  19. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Joseph, B., Malhi, H., Bhargava, K.K., Palestro, C.J., McCuskey, R.S., Gupta, S. Gastroenterology (2002) [Pubmed]
  20. Molecular cloning and expression of human hepatocyte growth factor. Nakamura, T., Nishizawa, T., Hagiya, M., Seki, T., Shimonishi, M., Sugimura, A., Tashiro, K., Shimizu, S. Nature (1989) [Pubmed]
  21. Purification and transplantation of hepatocytes from livers of carcinogen-treated rats. Miller, S.B., Pretlow, T.P., Scott, J.A., Pretlow, T.G. J. Natl. Cancer Inst. (1982) [Pubmed]
  22. A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats. Kogure, K., Omata, W., Kanzaki, M., Zhang, Y.Q., Yasuda, H., Mine, T., Kojima, I. Gastroenterology (1995) [Pubmed]
  23. Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion. Lesage, G., Glaser, S.S., Gubba, S., Robertson, W.E., Phinizy, J.L., Lasater, J., Rodgers, R.E., Alpini, G. Gastroenterology (1996) [Pubmed]
  24. Regenerating rat liver: correlations between estrogen receptor localization and deoxyribonucleic acid synthesis. Francavilla, A., di Leo, A., Eagon, P.K., Wu, S.Q., Ove, P., van Thiel, D.H., Starzl, T.E. Gastroenterology (1984) [Pubmed]
  25. Expression of a cellular oncogene during liver regeneration. Goyette, M., Petropoulos, C.J., Shank, P.R., Fausto, N. Science (1983) [Pubmed]
  26. Cytidine 3',5'-monophosphate phosphodiesterase: decreased activity in the regenerating and developing liver. Shoji, M., Brackett, N.L., Kuo, J.F. Science (1978) [Pubmed]
  27. The proinflammatory mediators C3a and C5a are essential for liver regeneration. Strey, C.W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L.A., Greenbaum, L.E., Lambris, J.D. J. Exp. Med. (2003) [Pubmed]
  28. Induction of gamma-glutamyltransferase-positive and nonspecific esterase-positive foci in rat liver by partial hepatectomy following single injection of N-nitrosodiethylamine. Hirota, N., Moriyama, S., Yokoyama, T. J. Natl. Cancer Inst. (1982) [Pubmed]
  29. Chronic ethanol administration to rats decreases receptor-operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5-inositol trisphosphate production: relevance to impaired liver regeneration. Zhang, B.H., Hornsfield, B.P., Farrell, G.C. J. Clin. Invest. (1996) [Pubmed]
  30. Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Peters, M., Blinn, G., Jostock, T., Schirmacher, P., Meyer zum Büschenfelde, K.H., Galle, P.R., Rose-John, S. Gastroenterology (2000) [Pubmed]
  31. ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. Selzner, N., Selzner, M., Odermatt, B., Tian, Y., Van Rooijen, N., Clavien, P.A. Gastroenterology (2003) [Pubmed]
  32. Met provides essential signals for liver regeneration. Borowiak, M., Garratt, A.N., Wüstefeld, T., Strehle, M., Trautwein, C., Birchmeier, C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  33. Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Rudnick, D.A., Perlmutter, D.H., Muglia, L.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  34. Ethanol inhibits liver regeneration in rats without reducing transcripts of key protooncogenes. Diehl, A.M., Thorgeirsson, S.S., Steer, C.J. Gastroenterology (1990) [Pubmed]
  35. Time-courses of hepatocellular hyperpolarization and cyclic adenosine 3',5'-monophosphate accumulation after partial hepatectomy in the rat. Effects of fasting for 48 hours and intravenous injection of glucose. Paloheimo, M., Linkola, J., Lempinen, M., Folke, M. Gastroenterology (1984) [Pubmed]
  36. Alpha-fetoprotein (AFP) in benign liver disease. Evidence that normal liver regeneration does not induce AFP synthesis. Alpert, E., Feller, E.R. Gastroenterology (1978) [Pubmed]
  37. CREB controls LAP/C/EBP beta transcription. Niehof, M., Manns, M.P., Trautwein, C. Mol. Cell. Biol. (1997) [Pubmed]
  38. Suppression of natural killer and lymphocyte functions associated with carcinogen-induced premalignant hyperplastic nodules in rat liver. Leu, R.W., Norton, T.R., Herriott, M.J., Ringer, D.P., Kearns, R.J. Cancer Res. (1985) [Pubmed]
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