- Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development. d'Oiron, R., Lavergne, J.M., Lavend'homme, R., Benhida, A., Bordet, J.C., Negrier, C., Peerlinck, K., Vermylen, J., Saint-Remy, J.M., Jacquemin, M. Blood (2004)