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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lomefloxacin concentrations in bone after a single oral dose.

We studied the penetration characteristics of lomefloxacin in bone in 30 patients with osteoarthritis undergoing total hip replacement. Patients were given a single oral 400 mg dose at various times from 1 to 12 hours prior to removal of bone samples. The peak plasma and bone (subchondral bone from femoral head) concentrations reached approximately 4.0 micrograms/mL at 2 hours post-dose and 3.0 micrograms/mL at 3 hours post-dose, respectively. At 12 hours post-dose both plasma and bone concentrations were still greater than 1.0 microgram/mL. Two hours after dosing the average bone-to-plasma ratio was greater than 0. 6. These data indicate that a single 400 mg oral dose of lomefloxacin attains bone concentrations that are above its usual minimum inhibitory concentrations for susceptible organisms.[1]


  1. Lomefloxacin concentrations in bone after a single oral dose. On, A., Nightingale, C.H., Quintiliani, R., Sweeney, K.R., Pasternak, H.S., Maderazo, E.G. Am. J. Med. (1992) [Pubmed]
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