The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Osteoarthritis


Psychiatry related information on Osteoarthritis


High impact information on Osteoarthritis


Chemical compound and disease context of Osteoarthritis


Biological context of Osteoarthritis


Anatomical context of Osteoarthritis


Gene context of Osteoarthritis


Analytical, diagnostic and therapeutic context of Osteoarthritis


  1. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. Taha, A.S., Hudson, N., Hawkey, C.J., Swannell, A.J., Trye, P.N., Cottrell, J., Mann, S.G., Simon, T.J., Sturrock, R.D., Russell, R.I. N. Engl. J. Med. (1996) [Pubmed]
  2. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Marcelino, J., Carpten, J.D., Suwairi, W.M., Gutierrez, O.M., Schwartz, S., Robbins, C., Sood, R., Makalowska, I., Baxevanis, A., Johnstone, B., Laxer, R.M., Zemel, L., Kim, C.A., Herd, J.K., Ihle, J., Williams, C., Johnson, M., Raman, V., Alonso, L.G., Brunoni, D., Gerstein, A., Papadopoulos, N., Bahabri, S.A., Trent, J.M., Warman, M.L. Nat. Genet. (1999) [Pubmed]
  3. Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. Vandenbroucke, J.P., Witteman, J.C., Valkenburg, H.A., Boersma, J.W., Cats, A., Festen, J.J., Hartman, A.P., Huber-Bruning, O., Rasker, J.J., Weber, J. JAMA (1986) [Pubmed]
  4. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Graham, D.Y., Agrawal, N.M., Roth, S.H. Lancet (1988) [Pubmed]
  5. Arthritis associated with apatite crystals. Schumacher, H.R., Smolyo, A.P., Tse, R.L., Maurer, K. Ann. Intern. Med. (1977) [Pubmed]
  6. Obesity and knee osteoarthritis. The Framingham Study. Felson, D.T., Anderson, J.J., Naimark, A., Walker, A.M., Meenan, R.F. Ann. Intern. Med. (1988) [Pubmed]
  7. Psychometric evaluation of the 12-item short-form health survey (SF-12) in osteoarthritis and rheumatoid arthritis clinical trials. Gandhi, S.K., Salmon, J.W., Zhao, S.Z., Lambert, B.L., Gore, P.R., Conrad, K. Clinical therapeutics. (2001) [Pubmed]
  8. The influence of pathology, pain, balance, and self-efficacy on function in women with osteoarthritis of the knee. Harrison, A.L. Physical therapy. (2004) [Pubmed]
  9. Pseudodementia associated with use of ibuprofen. Bernstein, A.L., Werlin, A. The Annals of pharmacotherapy. (2003) [Pubmed]
  10. Access to healthcare services among persons with osteoarthritis and rheumatoid arthritis. Hagglund, K.J., Clark, M.J., Hilton, S.A., Hewett, J.E. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. (2005) [Pubmed]
  11. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Kizawa, H., Kou, I., Iida, A., Sudo, A., Miyamoto, Y., Fukuda, A., Mabuchi, A., Kotani, A., Kawakami, A., Yamamoto, S., Uchida, A., Nakamura, K., Notoya, K., Nakamura, Y., Ikegawa, S. Nat. Genet. (2005) [Pubmed]
  12. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. Bradley, J.D., Brandt, K.D., Katz, B.P., Kalasinski, L.A., Ryan, S.I. N. Engl. J. Med. (1991) [Pubmed]
  13. Efficacy of glucosamine and chondroitin for treatment of osteoarthritis. Donohoe, M. JAMA (2000) [Pubmed]
  14. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. Langman, M.J., Jensen, D.M., Watson, D.J., Harper, S.E., Zhao, P.L., Quan, H., Bolognese, J.A., Simon, T.J. JAMA (1999) [Pubmed]
  15. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. Geba, G.P., Weaver, A.L., Polis, A.B., Dixon, M.E., Schnitzer, T.J. JAMA (2002) [Pubmed]
  16. Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. Amin, A.R., Attur, M., Patel, R.N., Thakker, G.D., Marshall, P.J., Rediske, J., Stuchin, S.A., Patel, I.R., Abramson, S.B. J. Clin. Invest. (1997) [Pubmed]
  17. Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis. Hashimoto, S., Takahashi, K., Ochs, R.L., Coutts, R.D., Amiel, D., Lotz, M. Arthritis Rheum. (1999) [Pubmed]
  18. Local steroid injections: comment on the American College of Rheumatology guidelines for the management of osteoarthritis of the hip and on the letter by Swezey. Neustadt, D.H. Arthritis Rheum. (1997) [Pubmed]
  19. Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids. Firestein, G.S., Paine, M.M., Littman, B.H. Arthritis Rheum. (1991) [Pubmed]
  20. Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Ota, F., Maeshima, A., Yamashita, S., Ikeuchi, H., Kaneko, Y., Kuroiwa, T., Hiromura, K., Ueki, K., Kojima, I., Nojima, Y. Arthritis Rheum. (2003) [Pubmed]
  21. Characterization and recruitment of plasmacytoid dendritic cells in synovial fluid and tissue of patients with chronic inflammatory arthritis. Lande, R., Giacomini, E., Serafini, B., Rosicarelli, B., Sebastiani, G.D., Minisola, G., Tarantino, U., Riccieri, V., Valesini, G., Coccia, E.M. J. Immunol. (2004) [Pubmed]
  22. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. Firestein, G.S., Xu, W.D., Townsend, K., Broide, D., Alvaro-Gracia, J., Glasebrook, A., Zvaifler, N.J. J. Exp. Med. (1988) [Pubmed]
  23. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis. Lotz, M., Moats, T., Villiger, P.M. J. Clin. Invest. (1992) [Pubmed]
  24. Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. Koch, A.E., Kunkel, S.L., Harlow, L.A., Mazarakis, D.D., Haines, G.K., Burdick, M.D., Pope, R.M., Walz, A., Strieter, R.M. J. Clin. Invest. (1994) [Pubmed]
  25. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. Postlethwaite, A.E., Holness, M.A., Katai, H., Raghow, R. J. Clin. Invest. (1992) [Pubmed]
  26. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. Sano, H., Hla, T., Maier, J.A., Crofford, L.J., Case, J.P., Maciag, T., Wilder, R.L. J. Clin. Invest. (1992) [Pubmed]
  27. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. Katsikis, P.D., Chu, C.Q., Brennan, F.M., Maini, R.N., Feldmann, M. J. Exp. Med. (1994) [Pubmed]
  28. Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. Seto, H., Kamekura, S., Miura, T., Yamamoto, A., Chikuda, H., Ogata, T., Hiraoka, H., Oda, H., Nakamura, K., Kurosawa, H., Chug, U.I., Kawaguchi, H., Tanaka, S. J. Clin. Invest. (2004) [Pubmed]
  29. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. Shouda, T., Yoshida, T., Hanada, T., Wakioka, T., Oishi, M., Miyoshi, K., Komiya, S., Kosai, K., Hanakawa, Y., Hashimoto, K., Nagata, K., Yoshimura, A. J. Clin. Invest. (2001) [Pubmed]
  30. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis.Rofecoxib Osteoarthritis Endoscopy Study Group. Laine, L., Harper, S., Simon, T., Bath, R., Johanson, J., Schwartz, H., Stern, S., Quan, H., Bolognese, J. Gastroenterology (1999) [Pubmed]
  31. A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. Gleghorn, L., Ramesar, R., Beighton, P., Wallis, G. Am. J. Hum. Genet. (2005) [Pubmed]
  32. A controlled evaluation of continuous passive motion in patients undergoing total knee arthroplasty. McInnes, J., Larson, M.G., Daltroy, L.H., Brown, T., Fossel, A.H., Eaton, H.M., Shulman-Kirwan, B., Steindorf, S., Poss, R., Liang, M.H. JAMA (1992) [Pubmed]
  33. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. McAlindon, T.E., LaValley, M.P., Gulin, J.P., Felson, D.T. JAMA (2000) [Pubmed]
  34. Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Zhang, Y.W., Su, Y., Lanning, N., Swiatek, P.J., Bronson, R.T., Sigler, R., Martin, R.W., Vande Woude, G.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  35. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Joosten, L.A., Netea, M.G., Kim, S.H., Yoon, D.Y., Oppers-Walgreen, B., Radstake, T.R., Barrera, P., van de Loo, F.A., Dinarello, C.A., van den Berg, W.B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  36. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Pelletier, J.P., Mineau, F., Raynauld, J.P., Woessner, J.F., Gunja-Smith, Z., Martel-Pelletier, J. Arthritis Rheum. (1994) [Pubmed]
WikiGenes - Universities