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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Lack of JC viral genomic sequences in multiple sclerosis brain tissue by polymerase chain reaction.

With DNA extracted from brain specimens from 19 multiple sclerosis, 5 progressive multifocal leukoencephalopathy, 1 Alzheimer's disease, and 8 nonneurological control subjects, polymerase chain reaction was performed using nested sets of primer pairs amplifying segments of the large T and VP1 antigen-encoding sequences of JC virus. Both sequences were detected in each of the 5 brain specimens of progressive multifocal leukoencephalopathy but in none of the 19 multiple sclerosis, 1 Alzheimer's disease, or the 8 control brain specimens.[1]

References

  1. Lack of JC viral genomic sequences in multiple sclerosis brain tissue by polymerase chain reaction. Buckle, G.J., Godec, M.S., Rubi, J.U., Tornatore, C., Major, E.O., Gibbs, C.J., Gajdusek, D.C., Asher, D.M. Ann. Neurol. (1992) [Pubmed]
 
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