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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

JC Virus

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Disease relevance of JC Virus


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Chemical compound and disease context of JC Virus


Biological context of JC Virus


Anatomical context of JC Virus


Gene context of JC Virus


Analytical, diagnostic and therapeutic context of JC Virus


  1. The POU domain protein Tst-1 and papovaviral large tumor antigen function synergistically to stimulate glia-specific gene expression of JC virus. Renner, K., Leger, H., Wegner, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. Suzuki, T., Okada, Y., Semba, S., Orba, Y., Yamanouchi, S., Endo, S., Tanaka, S., Fujita, T., Kuroda, S., Nagashima, K., Sawa, H. J. Biol. Chem. (2005) [Pubmed]
  3. Monoclonal antibody specific for BK virus large-T antigen allows discrimination among the different papovaviral large-T antigens. Marshall, J., Smith, A.E., Cheng, S.H. Oncogene (1991) [Pubmed]
  4. Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1. Raj, G.V., Safak, M., MacDonald, G.H., Khalili, K. J. Virol. (1996) [Pubmed]
  5. Analysis of capsid formation of human polyomavirus JC (Tokyo-1 strain) by a eukaryotic expression system: splicing of late RNAs, translation and nuclear transport of major capsid protein VP1, and capsid assembly. Shishido-Hara, Y., Hara, Y., Larson, T., Yasui, K., Nagashima, K., Stoner, G.L. J. Virol. (2000) [Pubmed]
  6. Lack of JC viral genomic sequences in multiple sclerosis brain tissue by polymerase chain reaction. Buckle, G.J., Godec, M.S., Rubi, J.U., Tornatore, C., Major, E.O., Gibbs, C.J., Gajdusek, D.C., Asher, D.M. Ann. Neurol. (1992) [Pubmed]
  7. Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo. Howard, C.M., Claudio, P.P., Gallia, G.L., Gordon, J., Giordano, G.G., Hauck, W.W., Khalili, K., Giordano, A. J. Natl. Cancer Inst. (1998) [Pubmed]
  8. Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element. Chen, N.N., Chang, C.F., Gallia, G.L., Kerr, D.A., Johnson, E.M., Krachmarov, C.P., Barr, S.M., Frisque, R.J., Bollag, B., Khalili, K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Brain vascular endothelial cells express JC virus large tumor antigen in immunocompetent and cyclophosphamide-treated hamsters. Ressetar, H.G., Webster, H.D., Stoner, G.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. Leger, H., Sock, E., Renner, K., Grummt, F., Wegner, M. Mol. Cell. Biol. (1995) [Pubmed]
  11. Immune surveillance in multiple sclerosis patients treated with natalizumab. Stüve, O., Marra, C.M., Jerome, K.R., Cook, L., Cravens, P.D., Cepok, S., Frohman, E.M., Phillips, J.T., Arendt, G., Hemmer, B., Monson, N.L., Racke, M.K. Ann. Neurol. (2006) [Pubmed]
  12. In situ polymerase chain reaction demonstration of JC virus in progressive multifocal leukoencephalopathy, including an index case. Ueki, K., Richardson, E.P., Henson, J.W., Louis, D.N. Ann. Neurol. (1994) [Pubmed]
  13. Differential distribution of the JC virus receptor-type sialic acid in normal human tissues. Eash, S., Tavares, R., Stopa, E.G., Robbins, S.H., Brossay, L., Atwood, W.J. Am. J. Pathol. (2004) [Pubmed]
  14. Stability and function of JC virus large T antigen and T' proteins are altered by mutation of their phosphorylated threonine 125 residues. Tyagarajan, S.K., Frisque, R.J. J. Virol. (2006) [Pubmed]
  15. Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids. Liu, C.K., Wei, G., Atwood, W.J. J. Virol. (1998) [Pubmed]
  16. Diagnosis of progressive multifocal leukoencephalopathy by brain biopsy with biotin labeled DNA:DNA in situ hybridization. Aksamit, A.J., Major, E.O., Ghatak, N.R., Sidhu, G.S., Parisi, J.E., Guccion, J.G. J. Neuropathol. Exp. Neurol. (1987) [Pubmed]
  17. Detection of JC virus DNA sequences and expression of the viral regulatory protein T-antigen in tumors of the central nervous system. Del Valle, L., Gordon, J., Assimakopoulou, M., Enam, S., Geddes, J.F., Varakis, J.N., Katsetos, C.D., Croul, S., Khalili, K. Cancer Res. (2001) [Pubmed]
  18. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Ricciardiello, L., Baglioni, M., Giovannini, C., Pariali, M., Cenacchi, G., Ripalti, A., Landini, M.P., Sawa, H., Nagashima, K., Frisque, R.J., Goel, A., Boland, C.R., Tognon, M., Roda, E., Bazzoli, F. Cancer Res. (2003) [Pubmed]
  19. Cell-specific activation of the glial-specific JC virus early promoter by large T antigen. Henson, J.W., Schnitker, B.L., Lee, T.S., McAllister, J. J. Biol. Chem. (1995) [Pubmed]
  20. Transcriptional activation of JC virus by human T-lymphotropic virus type I Tax protein in human neuronal cell lines. Okada, Y., Sawa, H., Tanaka, S., Takada, A., Suzuki, S., Hasegawa, H., Umemura, T., Fujisawa, J., Tanaka, Y., Hall, W.W., Nagashima, K. J. Biol. Chem. (2000) [Pubmed]
  21. Analysis of transcription control elements of the mouse myelin basic protein gene in HeLa cell extracts: demonstration of a strong NFI-binding motif in the upstream region. Tamura, T., Miura, M., Ikenaka, K., Mikoshiba, K. Nucleic Acids Res. (1988) [Pubmed]
  22. Progressive multifocal leukoencephalopathy in a patient with chronic myelogenous leukemia. Swamy, P.A., Nardino, R. Connecticut medicine. (2003) [Pubmed]
  23. Distribution of papovavirus, myelin-associated glycoprotein, and myelin basic protein in progressive multifocal leukoencephalopathy lesions. Itoyama, Y., Webster, H.D., Sternberger, N.H., Richardson, E.P., Walker, D.L., Quarles, R.H., Padgett, B.L. Ann. Neurol. (1982) [Pubmed]
  24. Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen. Lassak, A., Del Valle, L., Peruzzi, F., Wang, J.Y., Enam, S., Croul, S., Khalili, K., Reiss, K. J. Biol. Chem. (2002) [Pubmed]
  25. T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51. Trojanek, J., Croul, S., Ho, T., Wang, J.Y., Darbinyan, A., Nowicki, M., Valle, L.D., Skorski, T., Khalili, K., Reiss, K. J. Cell. Physiol. (2006) [Pubmed]
  26. Internalization of exogenous human immunodeficiency virus-1 protein, Tat, by KG-1 oligodendroglioma cells followed by stimulation of DNA replication initiated at the JC virus origin. Daniel, D.C., Kinoshita, Y., Khan, M.A., Valle, L.D., Khalili, K., Rappaport, J., Johnson, E.M. DNA Cell Biol. (2004) [Pubmed]
  27. An immunohistochemical study of p53 and proliferating cell nuclear antigen expression in progressive multifocal leukoencephalopathy. Lammie, G.A., Beckett, A., Courtney, R., Scaravilli, F. Acta Neuropathol. (1994) [Pubmed]
  28. Molecular cloning and expression of major structural protein VP1 of the human polyomavirus JC virus: formation of virus-like particles useful for immunological and therapeutic studies. Goldmann, C., Petry, H., Frye, S., Ast, O., Ebitsch, S., Jentsch, K.D., Kaup, F.J., Weber, F., Trebst, C., Nisslein, T., Hunsmann, G., Weber, T., Lüke, W. J. Virol. (1999) [Pubmed]
  29. Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient. Milstone, A., Vilchez, R.A., Geiger, X., Fogo, A.B., Butel, J.S., Dummer, S. Transplantation (2004) [Pubmed]
  30. Highly active antiretroviral therapy and progressive multifocal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response. Giudici, B., Vaz, B., Bossolasco, S., Casari, S., Brambilla, A.M., Lüke, W., Lazzarin, A., Weber, T., Cinque, P. Clin. Infect. Dis. (2000) [Pubmed]
  31. Immunolabeling of JC virus large T antigen in neonatal hamster brain before tumor formation. Ressetar, H.G., Walker, D.L., Webster, H.D., Braun, D.G., Stoner, G.L. Lab. Invest. (1990) [Pubmed]
  32. Transcriptional activation of JC virus early promoter by phorbol ester and interleukin-1beta: critical role of nuclear factor-1. Kim, S.Y., Choi, E.C., Woo Jo, Y., Henson, J.W., Kim, H.S. Virology (2004) [Pubmed]
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