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Antilipoxygenase activity of amyrin triterpenes.

Triterpenes--alpha-amyrin acetate, beta-amyrin acetate and beta-amyrin were tested for their effects on the synthesis of 5-lipoxygenase products in human neutrophils. All the triterpenes reduced 5-HETE synthesis without effect on LTB4 synthesis. The relative effects suggest that 5-HETE inhibition can explain the antiarthritic activity possessed by these compounds.[1]


  1. Antilipoxygenase activity of amyrin triterpenes. Kweifio-Okai, G., Macrides, T.A. Res. Commun. Chem. Pathol. Pharmacol. (1992) [Pubmed]
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