Gene Review:
ALOX5 - arachidonate 5-lipoxygenase
Homo sapiens
Synonyms:
5-LO, 5-LOX, 5-lipoxygenase, 5LPG, Arachidonate 5-lipoxygenase, ...
Kannan,
Lima,
Zhang,
Grant,
Shao,
Tantisira,
Allayee,
Wang,
Sylvester,
Holbrook,
Wise,
Weiss,
Barnes,
Drazen,
Yandava,
Dubé,
Szczerback,
Hippensteel,
Pillari,
Israel,
Schork,
Silverman,
Katz,
Drajesk,
Cianchi,
Cortesini,
Magnelli,
Fanti,
Papucci,
Schiavone,
Messerini,
Vannacci,
Capaccioli,
Perna,
Lulli,
Fabbroni,
Perigli,
Bechi,
Masini,
Brune,
McCarty,
Werz,
Tretiakova,
Michel,
Ulke-Lemee,
Hörnig,
Franke,
Schneider,
Samuelsson,
Rådmark,
Steinhilber,
de Gaetano,
Donati,
Cerletti,
Ghosh,
Gupta,
Nicholson,
Ford-Hutchinson,
Chen,
Wang,
Wu,
Sood,
Wang,
Jin,
Beer,
Giordano,
Lin,
Shih,
Lubet,
Yang,
- Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Goodman, J.E., Bowman, E.D., Chanock, S.J., Alberg, A.J., Harris, C.C. Carcinogenesis (2004)
- Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population. Kim, S.H., Choi, J.H., Holloway, J.W., Suh, C.H., Nahm, D.H., Ha, E.H., Park, C.S., Park, H.S. J. Korean Med. Sci. (2005)
- Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors. de Gaetano, G., Donati, M.B., Cerletti, C. Trends Pharmacol. Sci. (2003)
- Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators. Kowal-Bielecka, O., Kowal, K., Distler, O., Rojewska, J., Bodzenta-Lukaszyk, A., Michel, B.A., Gay, R.E., Gay, S., Sierakowski, S. Arthritis Rheum. (2005)
- Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. Adamjee, J., Suh, Y.J., Park, H.S., Choi, J.H., Penrose, J.F., Lam, B.K., Austen, K.F., Cazaly, A.M., Wilson, S.J., Sampson, A.P. J. Pathol. (2006)
- 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease. Manev, H., Manev, R. Med. Hypotheses (2006)
- Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase. Nguyen, T., Falgueyret, J.P., Abramovitz, M., Riendeau, D. J. Biol. Chem. (1991)
- A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events. McCarty, M.F. Med. Hypotheses (2004)
- The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N.J., Gudmundsson, G., Grant, S.F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Johannsson, H., Gudmundsdottir, O., Gurney, M.E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M.L., Topol, E.J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J.R., Stefansson, K. Nat. Genet. (2004)
- Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Drazen, J.M., Yandava, C.N., Dubé, L., Szczerback, N., Hippensteel, R., Pillari, A., Israel, E., Schork, N., Silverman, E.S., Katz, D.A., Drajesk, J. Nat. Genet. (1999)
- Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis. Chen, X., Wang, S., Wu, N., Sood, S., Wang, P., Jin, Z., Beer, D.G., Giordano, T.J., Lin, Y., Shih, W.C., Lubet, R.A., Yang, C.S. Clin. Cancer Res. (2004)
- 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones. Bhatia, P.A., Brooks, C.D., Basha, A., Ratajczyk, J.D., Gunn, B.P., Bouska, J.B., Lanni, C., Young, P.R., Bell, R.L., Carter, G.W. J. Med. Chem. (1996)
- Safety of anti-inflammatory treatment--new ways of thinking. Brune, K. Rheumatology (Oxford, England) (2004)
- Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. Cianchi, F., Cortesini, C., Magnelli, L., Fanti, E., Papucci, L., Schiavone, N., Messerini, L., Vannacci, A., Capaccioli, S., Perna, F., Lulli, M., Fabbroni, V., Perigli, G., Bechi, P., Masini, E. Mol. Cancer Ther. (2006)
- Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Lima, J.J., Zhang, S., Grant, A., Shao, L., Tantisira, K.G., Allayee, H., Wang, J., Sylvester, J., Holbrook, J., Wise, R., Weiss, S.T., Barnes, K. Am. J. Respir. Crit. Care Med. (2006)
- Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers, I., Barton, S., Rorke, S., Sawyer, J., Peng, Q., Beghé, B., Ye, S., Keith, T., Clough, J.B., Holloway, J.W., Sampson, A.P., Holgate, S.T. Clin. Exp. Allergy (2003)
- Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Choi, J.H., Park, H.S., Oh, H.B., Lee, J.H., Suh, Y.J., Park, C.S., Shin, H.D. Hum. Genet. (2004)
- 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Werz, O., Klemm, J., Samuelsson, B., Rådmark, O. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. Werz, O., Tretiakova, I., Michel, A., Ulke-Lemee, A., Hörnig, M., Franke, L., Schneider, G., Samuelsson, B., Rådmark, O., Steinhilber, D. Proc. Natl. Acad. Sci. U.S.A. (2005)
- 5-Lipoxygenase expression in Langerhans cells of normal human epidermis. Spanbroek, R., Stark, H.J., Janssen-Timmen, U., Kraft, S., Hildner, M., Andl, T., Bosch, F.X., Fusenig, N.E., Bieber, T., Rådmark, O., Samuelsson, B., Habenicht, A.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Qiu, H., Gabrielsen, A., Agardh, H.E., Wan, M., Wetterholm, A., Wong, C.H., Hedin, U., Swedenborg, J., Hansson, G.K., Samuelsson, B., Paulsson-Berne, G., Haeggström, J.Z. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness. Kim, S.H., Bae, J.S., Suh, C.H., Nahm, D.H., Holloway, J.W., Park, H.S. Allergy (2005)
- 5-Lipoxygenase interacts with coactosin-like protein. Provost, P., Doucet, J., Hammarberg, T., Gerisch, G., Samuelsson, B., Radmark, O. J. Biol. Chem. (2001)
- 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. Lepley, R.A., Fitzpatrick, F.A. J. Biol. Chem. (1994)
- Pharmacological cross-reactivity between 5-lipoxygenase-activating protein, 5-lipoxygenase, and leukotriene C4 synthase. Gupta, N., Nicholson, D.W., Ford-Hutchinson, A.W. Can. J. Physiol. Pharmacol. (1997)
- The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. Steinhilber, D., Brungs, M., Werz, O., Wiesenberg, I., Danielsson, C., Kahlen, J.P., Nayeri, S., Schräder, M., Carlberg, C. J. Biol. Chem. (1995)
- Inflammation: a novel mechanism for the transport of extracellular nucleotide-induced arachidonic acid by S100A8/A9 for transcellular metabolism. Kannan, S. Cell Biol. Int. (2003)
- Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Ghosh, J. Biochem. Biophys. Res. Commun. (2003)
- 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. Wright, L., Tuder, R.M., Wang, J., Cool, C.D., Lepley, R.A., Voelkel, N.F. Am. J. Respir. Crit. Care Med. (1998)
- Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes. Jakobsson, P.J., Shaskin, P., Larsson, P., Feltenmark, S., Odlander, B., Aguilar-Santelises, M., Jondal, M., Biberfeld, P., Claesson, H.E. Eur. J. Biochem. (1995)
- Selenium-dependent peroxidases suppress 5-lipoxygenase activity in B-lymphocytes and immature myeloid cells. The presence of peroxidase-insensitive 5-lipoxygenase activity in differentiated myeloid cells. Werz, O., Steinhilber, D. Eur. J. Biochem. (1996)
- Interaction of 5-lipoxygenase with cellular proteins. Provost, P., Samuelsson, B., Rådmark, O. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1. Bürkert, E., Arnold, C., Hammarberg, T., Rådmark, O., Steinhilber, D., Werz, O. J. Biol. Chem. (2003)
- Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). Werz, O., Szellas, D., Steinhilber, D., Rådmark, O. J. Biol. Chem. (2002)