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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Competition for overlapping sites in the regulatory region of the Drosophila gene Krüppel.

A 730-base pair element regulates expression of the Drosophila gap gene Krüppel (Kr) in response to the fly anterior morphogen bicoid (bcd). Two hormone receptor-like proteins, encoded by the genes knirps (kni) and tailless (tll), bind specifically to the element. In vitro, kni protein competes with the homeodomain-containing bcd protein in binding to a 16-base pair target sequence. In vivo experiments suggest that both kni and tll act as competitive repressors of bcd- mediated activation of Kr. These results suggest a mechanism by which developmental genes can be regulated in response to an activating morphogen gradient antagonized by repressors.[1]

References

  1. Competition for overlapping sites in the regulatory region of the Drosophila gene Krüppel. Hoch, M., Gerwin, N., Taubert, H., Jäckle, H. Science (1992) [Pubmed]
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