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MeSH Review

Genes, Developmental

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Disease relevance of Genes, Developmental


High impact information on Genes, Developmental

  • Pbx1 is a member of the TALE (three-amino acid loop extension) class of homeodomain transcription factors, which are components of hetero-oligomeric protein complexes thought to regulate developmental gene expression and to maintain differentiated cell states [6].
  • The developmental gene, PAX2, located within this region, is an attractive candidate gene [7].
  • The Viviparous-1 developmental gene of maize encodes a novel transcriptional activator [8].
  • The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity [9].
  • DNA complementary to Pit-1 mRNA, cloned on the basis of specific binding to AT-rich cell-specific elements in the rat prolactin and growth hormone genes, encodes a 33 kd protein with significant similarity at its carboxyl terminus to the homeodomains encoded by Drosophila developmental genes [10].

Chemical compound and disease context of Genes, Developmental


Biological context of Genes, Developmental


Anatomical context of Genes, Developmental


Associations of Genes, Developmental with chemical compounds


Gene context of Genes, Developmental

  • Thus, like the promoters of the key developmental genes, HO and IME1, the FLO11 promoter is large and complex, endowing it with the ability to integrate multiple inputs [27].
  • Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes [28].
  • Hedgehog controls the expression of key developmental genes through the conversion of the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (Ci[rep]) form [29].
  • By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions [30].
  • These results indicate that Ptc heterozygosity contributes to tumorigenesis by predisposing a subset of granule cell precursors to the formation of proliferative rests and subsequent dysregulation of developmental gene expression [31].

Analytical, diagnostic and therapeutic context of Genes, Developmental


  1. Ectopic production of guanosine penta- and tetraphosphate can initiate early developmental gene expression in Myxococcus xanthus. Singer, M., Kaiser, D. Genes Dev. (1995) [Pubmed]
  2. Evaluation of the RET regulatory landscape reveals the biological relevance of a HSCR-implicated enhancer. Grice, E.A., Rochelle, E.S., Green, E.D., Chakravarti, A., McCallion, A.S. Hum. Mol. Genet. (2005) [Pubmed]
  3. Functional characterization of sonic hedgehog mutations associated with holoprosencephaly. Traiffort, E., Dubourg, C., Faure, H., Rognan, D., Odent, S., Durou, M.R., David, V., Ruat, M. J. Biol. Chem. (2004) [Pubmed]
  4. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. Terada, Y., Tanaka, H., Okado, T., Shimamura, H., Inoshita, S., Kuwahara, M., Sasaki, S. J. Am. Soc. Nephrol. (2003) [Pubmed]
  5. Control of developmental gene expression by cell-to-cell interactions in Myxococcus xanthus. Gill, R.E., Cull, M.G. J. Bacteriol. (1986) [Pubmed]
  6. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Kim, S.K., Selleri, L., Lee, J.S., Zhang, A.Y., Gu, X., Jacobs, Y., Cleary, M.L. Nat. Genet. (2002) [Pubmed]
  7. A gene for Crouzon craniofacial dysostosis maps to the long arm of chromosome 10. Preston, R.A., Post, J.C., Keats, B.J., Aston, C.E., Ferrell, R.E., Priest, J., Nouri, N., Losken, H.W., Morris, C.A., Hurtt, M.R. Nat. Genet. (1994) [Pubmed]
  8. The Viviparous-1 developmental gene of maize encodes a novel transcriptional activator. McCarty, D.R., Hattori, T., Carson, C.B., Vasil, V., Lazar, M., Vasil, I.K. Cell (1991) [Pubmed]
  9. The sequence specificity of homeodomain-DNA interaction. Desplan, C., Theis, J., O'Farrell, P.H. Cell (1988) [Pubmed]
  10. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Ingraham, H.A., Chen, R.P., Mangalam, H.J., Elsholtz, H.P., Flynn, S.E., Lin, C.R., Simmons, D.M., Swanson, L., Rosenfeld, M.G. Cell (1988) [Pubmed]
  11. Myxococcus xanthus sasS encodes a sensor histidine kinase required for early developmental gene expression. Yang, C., Kaplan, H.B. J. Bacteriol. (1997) [Pubmed]
  12. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., Shinkai, Y. Genes Dev. (2002) [Pubmed]
  13. Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Kim, S.W., Park, J.I., Spring, C.M., Sater, A.K., Ji, H., Otchere, A.A., Daniel, J.M., McCrea, P.D. Nat. Cell Biol. (2004) [Pubmed]
  14. Two histone fold proteins, CHRAC-14 and CHRAC-16, are developmentally regulated subunits of chromatin accessibility complex (CHRAC). Corona, D.F., Eberharter, A., Budde, A., Deuring, R., Ferrari, S., Varga-Weisz, P., Wilm, M., Tamkun, J., Becker, P.B. EMBO J. (2000) [Pubmed]
  15. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. García, E., Marcos-Gutiérrez, C., del Mar Lorente, M., Moreno, J.C., Vidal, M. EMBO J. (1999) [Pubmed]
  16. Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice. Porteous, S., Torban, E., Cho, N.P., Cunliffe, H., Chua, L., McNoe, L., Ward, T., Souza, C., Gus, P., Giugliani, R., Sato, T., Yun, K., Favor, J., Sicotte, M., Goodyer, P., Eccles, M. Hum. Mol. Genet. (2000) [Pubmed]
  17. Developmental regulation and expression of the zebrafish connexin43 gene. Chatterjee, B., Chin, A.J., Valdimarsson, G., Finis, C., Sonntag, J.M., Choi, B.Y., Tao, L., Balasubramanian, K., Bell, C., Krufka, A., Kozlowski, D.J., Johnson, R.G., Lo, C.W. Dev. Dyn. (2005) [Pubmed]
  18. Pax-2: a developmental gene constitutively expressed in the mouse epididymis and ductus deferens. Oefelein, M., Grapey, D., Schaeffer, T., Chin-Chance, C., Bushman, W. J. Urol. (1996) [Pubmed]
  19. A ventral pontine pathway promotes rhythmic activity in the medulla of neonate mice. Borday, V., Kato, F., Champagnat, J. Neuroreport (1997) [Pubmed]
  20. An insertional mutation in the BTF3 transcription factor gene leads to an early postimplantation lethality in mice. Deng, J.M., Behringer, R.R. Transgenic Res. (1995) [Pubmed]
  21. Developmental gene expression of lactoferrin in duodenum and effect of weaning age on gene expression of lactoferrin in piglets. Wang, Y., Han, F., Xu, Z. Archives of animal nutrition. (2006) [Pubmed]
  22. The systemin precursor gene regulates both defensive and developmental genes in Solanum tuberosum. Narváez-Vasquez, J., Ryan, C.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  23. Functional promiscuity of gene regulation by serpentine receptors in Dictyostelium discoideum. Verkerke-Van Wijk, I., Kim, J.Y., Brandt, R., Devreotes, P.N., Schaap, P. Mol. Cell. Biol. (1998) [Pubmed]
  24. Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. Eissenberg, J.C., Wong, M., Chrivia, J.C. Mol. Cell. Biol. (2005) [Pubmed]
  25. Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. Ruberte, E., Friederich, V., Morriss-Kay, G., Chambon, P. Development (1992) [Pubmed]
  26. Identification of a second human nm23 gene, nm23-H2. Stahl, J.A., Leone, A., Rosengard, A.M., Porter, L., King, C.R., Steeg, P.S. Cancer Res. (1991) [Pubmed]
  27. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. Rupp, S., Summers, E., Lo, H.J., Madhani, H., Fink, G. EMBO J. (1999) [Pubmed]
  28. Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. Chen, Y., Weeks, J., Mortin, M.A., Greenleaf, A.L. Mol. Cell. Biol. (1993) [Pubmed]
  29. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Méthot, N., Basler, K. Development (2000) [Pubmed]
  30. A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Yan, Y.L., Willoughby, J., Liu, D., Crump, J.G., Wilson, C., Miller, C.T., Singer, A., Kimmel, C., Westerfield, M., Postlethwait, J.H. Development (2005) [Pubmed]
  31. Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Kim, J.Y., Nelson, A.L., Algon, S.A., Graves, O., Sturla, L.M., Goumnerova, L.C., Rowitch, D.H., Segal, R.A., Pomeroy, S.L. Dev. Biol. (2003) [Pubmed]
  32. Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6. Tang, H.K., Singh, S., Saunders, G.F. J. Biol. Chem. (1998) [Pubmed]
  33. Acceleration of early chick embryo morphogenesis by insulin is associated with altered expression of embryonic genes. Patwardhan, V., Gokhale, M., Ghaskadbi, S. Int. J. Dev. Biol. (2004) [Pubmed]
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