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MeSH Review

Genes, Developmental

 
 
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Disease relevance of Genes, Developmental

 

High impact information on Genes, Developmental

  • Pbx1 is a member of the TALE (three-amino acid loop extension) class of homeodomain transcription factors, which are components of hetero-oligomeric protein complexes thought to regulate developmental gene expression and to maintain differentiated cell states [6].
  • The developmental gene, PAX2, located within this region, is an attractive candidate gene [7].
  • The Viviparous-1 developmental gene of maize encodes a novel transcriptional activator [8].
  • The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity [9].
  • DNA complementary to Pit-1 mRNA, cloned on the basis of specific binding to AT-rich cell-specific elements in the rat prolactin and growth hormone genes, encodes a 33 kd protein with significant similarity at its carboxyl terminus to the homeodomains encoded by Drosophila developmental genes [10].
 

Chemical compound and disease context of Genes, Developmental

 

Biological context of Genes, Developmental

 

Anatomical context of Genes, Developmental

 

Associations of Genes, Developmental with chemical compounds

 

Gene context of Genes, Developmental

  • Thus, like the promoters of the key developmental genes, HO and IME1, the FLO11 promoter is large and complex, endowing it with the ability to integrate multiple inputs [27].
  • Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes [28].
  • Hedgehog controls the expression of key developmental genes through the conversion of the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (Ci[rep]) form [29].
  • By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions [30].
  • These results indicate that Ptc heterozygosity contributes to tumorigenesis by predisposing a subset of granule cell precursors to the formation of proliferative rests and subsequent dysregulation of developmental gene expression [31].
 

Analytical, diagnostic and therapeutic context of Genes, Developmental

References

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  18. Pax-2: a developmental gene constitutively expressed in the mouse epididymis and ductus deferens. Oefelein, M., Grapey, D., Schaeffer, T., Chin-Chance, C., Bushman, W. J. Urol. (1996) [Pubmed]
  19. A ventral pontine pathway promotes rhythmic activity in the medulla of neonate mice. Borday, V., Kato, F., Champagnat, J. Neuroreport (1997) [Pubmed]
  20. An insertional mutation in the BTF3 transcription factor gene leads to an early postimplantation lethality in mice. Deng, J.M., Behringer, R.R. Transgenic Res. (1995) [Pubmed]
  21. Developmental gene expression of lactoferrin in duodenum and effect of weaning age on gene expression of lactoferrin in piglets. Wang, Y., Han, F., Xu, Z. Archives of animal nutrition. (2006) [Pubmed]
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  24. Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. Eissenberg, J.C., Wong, M., Chrivia, J.C. Mol. Cell. Biol. (2005) [Pubmed]
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  27. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. Rupp, S., Summers, E., Lo, H.J., Madhani, H., Fink, G. EMBO J. (1999) [Pubmed]
  28. Mapping mutations in genes encoding the two large subunits of Drosophila RNA polymerase II defines domains essential for basic transcription functions and for proper expression of developmental genes. Chen, Y., Weeks, J., Mortin, M.A., Greenleaf, A.L. Mol. Cell. Biol. (1993) [Pubmed]
  29. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Méthot, N., Basler, K. Development (2000) [Pubmed]
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