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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ambruticin S production in air-lift and stirred-tank bioreactors.

Using the method of equi-inocular synchronized comparative fermentation (EISCF) the cultivation of Sorangium cellulosum So ce 10 and production of the polyketide antibiotic ambruticin S was compared in stirred-tank and air-lift reactors of different geometry. This method requires that inocula originate from the same pre-culture and cultivation parameters are synchronized to similar values. Similar ambruticin yields were obtained from both reactor systems provided that the concentration of dissolved oxygen (DO) was maintained above a certain value (ca. 40%). For cultivation of S. cellulosum it is the DO level rather than the oxygen transfer rate which presents the proper criterion for scale-up and comparative reactor studies.[1]


  1. Ambruticin S production in air-lift and stirred-tank bioreactors. Hopf, N.W., Yonsel, S., Deckwer, W.D. Appl. Microbiol. Biotechnol. (1990) [Pubmed]
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