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Disease relevance of Bioreactors


High impact information on Bioreactors

  • AIR-controlled interferon-beta production in transgenic CHO-K1-derived serum-free suspension cultures could be modulated by fine-tuning inflow and outflow of acetaldehyde-containing gas during standard bioreactor operation [6].
  • Finally, stereospecific production (>99%) of L-alanine was achieved by disrupting the gene encoding alanine racemase, opening the door to the industrial production of this stereoisomer in food products or bioreactors [7].
  • The leachate that resulted from the action of sulfur-oxidizing bacteria on contaminated soil was stripped of metals using an anaerobic bioreactor containing a mixed culture of sulfate-reducing bacteria which precipitated soluble metal species as solid metal sulfides [8].
  • Cochallenge of the cells with Ni2+ and UO2(2+), and glycerol 2-phosphate (phosphate donor for phosphate release and metal bioprecipitation) gave sustained removal of both metals in a flow through bioreactor, with more extensively accumulated Ni [9].
  • By optimization of cell growth conditions in a bioreactor, WT opsin, a constitutively active opsin mutant, E113Q/E134Q/M257Y, presumed to be toxic to the cells, and nonglycosylated WT opsin obtained by growth in the presence of tunicamycin have been prepared in amounts of several milligrams per liter of culture medium [10].

Chemical compound and disease context of Bioreactors

  • As a first step to understanding such interactions, we performed bioreactor experiments under continuous flow to study the effect of a biofilm of the sulfate-reducing bacterium Desulfovibrio desulfuricans attached to specular hematite (alpha-Fe2O3) surfaces on surface-associated U(VI) complexation, transformation, and mobility [11].
  • High-rate continuous production of lactic acid by Lactobacillus rhamnosus in a two-stage membrane cell-recycle bioreactor [12].
  • Process development for degradation of phenol by Pseudomonas putida in hollow-fiber membrane bioreactors [13].
  • The dissolved O2 concentration profile within a single HF (lumen, membrane, and representative extra capillary space (ECS)) was modeled with the finite element method, and compared to experimentally measured data obtained on an actual HF bioreactor with the same dimensions housing C3A hepatoma cells [14].
  • A bioreactor inoculated with Pseudomonas sp. strain JS150 was submitted to successive step disturbances in the MCB load, inducing washout and system instability [15].

Biological context of Bioreactors


Anatomical context of Bioreactors

  • Amino-terminal peptide sequencing confirmed the identity of this material as a bTAP isoform. bTAP available from a mammary gland bioreactor will allow evaluation of bTAP for use as an antibiotic in agriculture and medicine [21].
  • METHODS: Tissue sections from native and trypsin-digested bovine nasal cartilage (BNC) and from engineered cartilage, generated by chick sternal chondrocytes grown in a hollow fiber bioreactor, were placed either on calcium fluoride windows for FTIR analysis or gelatinized microscope slides for histologic analysis [22].
  • We previously reported a novel method to generate AAV based on an AAV Rep/Cap-containing cell line (B50) and an Ad-AAV hybrid virus, which is amenable to scale-up in bioreactors [23].
  • METHODS: The bioreactor consists of a spirally wound nonwoven polyester matrix, i.e. a sheet-shaped, three-dimensional framework for hepatocyte immobilization and aggregation, and of integrated hydrophobic hollow-fiber membranes for decentralized oxygen supply and CO2 removal [24].
  • TEM with colloidal lanthanum tracer revealed that only bioreactor islet cell cultures were devoid of tight junctional complexes, which may facilitate channel formation [25].

Associations of Bioreactors with chemical compounds

  • Continuous ethanol production by flocculating yeast in the fluidized bed bioreactor [26].
  • Recently, a method was developed in which beta-carotene was harvested from the microalga Dunaliella salina grown in a two-phase bioreactor [27].
  • An aliquot (5 x 10(7)) of PBL apheresis product was precultured in a gas-permeable culture bag or a bioreactor, and then transduced with a retroviral vector L2SN containing the iduronate-2-sulfatase (IDS) and neomycin resistance genes [28].
  • Significantly lower levels of ammonia and lactate in the LIS Cell-BAL group indicated that the porcine hepatocytes in the bioreactor were metabolically activity [29].
  • Operation of ion-selective electrode detectors in the sub-Nernstian/linear response range: application to flow-injection/enzymatic determination of L-glutamine in bioreactor media [30].

Gene context of Bioreactors


Analytical, diagnostic and therapeutic context of Bioreactors


  1. Improved gene transfer and normalized enzyme levels in primitive hematopoietic progenitors from patients with mucopolysaccharidosis type I using a bioreactor. Pan, D., Stroncek, D.F., Whitley, C.B. The journal of gene medicine. (2004) [Pubmed]
  2. Performance characterization of a model bioreactor for the biodegradation of trichloroethylene by Pseudomonas cepacia G4. Folsom, B.R., Chapman, P.J. Appl. Environ. Microbiol. (1991) [Pubmed]
  3. Cloning and characterization of a gene cluster for cyclododecanone oxidation in Rhodococcus ruber SC1. Kostichka, K., Thomas, S.M., Gibson, K.J., Nagarajan, V., Cheng, Q. J. Bacteriol. (2001) [Pubmed]
  4. Reduction of technetium by Desulfovibrio desulfuricans: biocatalyst characterization and use in a flowthrough bioreactor. Lloyd, J.R., Ridley, J., Khizniak, T., Lyalikova, N.N., Macaskie, L.E. Appl. Environ. Microbiol. (1999) [Pubmed]
  5. Optimized analysis of intracellular adenosine and guanosine phosphates in Escherichia coli. Meyer, S., Noisommit-Rizzi, N., Reuss, M., Neubauer, P. Anal. Biochem. (1999) [Pubmed]
  6. Gas-inducible transgene expression in mammalian cells and mice. Weber, W., Rimann, M., Spielmann, M., Keller, B., Daoud-El Baba, M., Aubel, D., Weber, C.C., Fussenegger, M. Nat. Biotechnol. (2004) [Pubmed]
  7. Conversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering. Hols, P., Kleerebezem, M., Schanck, A.N., Ferain, T., Hugenholtz, J., Delcour, J., de Vos, W.M. Nat. Biotechnol. (1999) [Pubmed]
  8. An integrated microbial process for the bioremediation of soil contaminated with toxic metals. White, C., Sharman, A.K., Gadd, G.M. Nat. Biotechnol. (1998) [Pubmed]
  9. Bioaccumulation of nickel by intercalation into polycrystalline hydrogen uranyl phosphate deposited via an enzymatic mechanism. Bonthrone, K.M., Basnakova, G., Lin, F., Macaskie, L.E. Nat. Biotechnol. (1996) [Pubmed]
  10. Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants. Reeves, P.J., Kim, J.M., Khorana, H.G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. Uranium complexes formed at hematite surfaces colonized by sulfate-reducing bacteria. Neal, A.L., Amonette, J.E., Peyton, B.M., Geesey, G.G. Environ. Sci. Technol. (2004) [Pubmed]
  12. High-rate continuous production of lactic acid by Lactobacillus rhamnosus in a two-stage membrane cell-recycle bioreactor. Kwon, S., Yoo, I.K., Lee, W.G., Chang, H.N., Chang, Y.K. Biotechnol. Bioeng. (2001) [Pubmed]
  13. Process development for degradation of phenol by Pseudomonas putida in hollow-fiber membrane bioreactors. Chung, T.P., Wu, P.C., Juang, R.S. Biotechnol. Bioeng. (2004) [Pubmed]
  14. Simulation of oxygen carrier mediated oxygen transport to C3A hepatoma cells housed within a hollow fiber bioreactor. Sullivan, J.P., Gordon, J.E., Palmer, A.F. Biotechnol. Bioeng. (2006) [Pubmed]
  15. Bioscrubbing of waste gas-substrate absorber to avoid instability induced by inhibition kinetics. Oliveira, T.A., Livingston, A.G. Biotechnol. Bioeng. (2003) [Pubmed]
  16. Liver micro-organs transcribe albumin and clotting factors and increase survival of 92% hepatectomized rats. Grad-Itach, E., Fuchs, A.G., Lev, H., Kotok, T., Shemesh, R., Shouval, D., Ilan, Y., Mitrani, E. J. Hepatol. (2003) [Pubmed]
  17. Purification and characterization of recombinant human thyrotropin (TSH) isoforms produced by Chinese hamster ovary cells: the role of sialylation and sulfation in TSH bioactivity. Szkudlinski, M.W., Thotakura, N.R., Bucci, I., Joshi, L.R., Tsai, A., East-Palmer, J., Shiloach, J., Weintraub, B.D. Endocrinology (1993) [Pubmed]
  18. Chlorophenol degradation coupled to sulfate reduction. Häggblom, M.M., Young, L.Y. Appl. Environ. Microbiol. (1990) [Pubmed]
  19. Comparison of 2,4-dichlorophenoxyacetic acid degradation and plasmid transfer in soil resulting from bioaugmentation with two different pJP4 donors. Newby, D.T., Gentry, T.J., Pepper, I.L. Appl. Environ. Microbiol. (2000) [Pubmed]
  20. Microbiology of a nitrite-oxidizing bioreactor. Burrell, P.C., Keller, J., Blackall, L.L. Appl. Environ. Microbiol. (1998) [Pubmed]
  21. Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. Yarus, S., Rosen, J.M., Cole, A.M., Diamond, G. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  22. Imaging of collagen and proteoglycan in cartilage sections using Fourier transform infrared spectral imaging. Potter, K., Kidder, L.H., Levin, I.W., Lewis, E.N., Spencer, R.G. Arthritis Rheum. (2001) [Pubmed]
  23. Purification of recombinant adeno-associated virus vectors by column chromatography and its performance in vivo. Gao, G., Qu, G., Burnham, M.S., Huang, J., Chirmule, N., Joshi, B., Yu, Q.C., Marsh, J.A., Conceicao, C.M., Wilson, J.M. Hum. Gene Ther. (2000) [Pubmed]
  24. In vitro evaluation of a novel bioreactor based on an integral oxygenator and a spirally wound nonwoven polyester matrix for hepatocyte culture as small aggregates. Flendrig, L.M., la Soe, J.W., Jörning, G.G., Steenbeek, A., Karlsen, O.T., Bovée, W.M., Ladiges, N.C., te Velde, A.A., Chamuleau, R.A. J. Hepatol. (1997) [Pubmed]
  25. Microgravity culture condition reduces immunogenicity and improves function of pancreatic islets1. Rutzky, L.P., Bilinski, S., Kloc, M., Phan, T., Zhang, H., Katz, S.M., Stepkowski, S.M. Transplantation (2002) [Pubmed]
  26. Continuous ethanol production by flocculating yeast in the fluidized bed bioreactor. Wieczorek, A., Michalski, H. FEMS Microbiol. Rev. (1994) [Pubmed]
  27. Milking of microalgae. Hejazi, M.A., Wijffels, R.H. Trends Biotechnol. (2004) [Pubmed]
  28. Combined ultrafiltration-transduction in a hollow-fiber bioreactor facilitates retrovirus-mediated gene transfer into peripheral blood lymphocytes from patients with mucopolysaccharidosis type II. Pan, D., Shankar, R., Stroncek, D.F., Whitley, C.B. Hum. Gene Ther. (1999) [Pubmed]
  29. Evaluation of a novel bioartificial liver in rats with complete liver ischemia: treatment efficacy and species-specific alpha-GST detection to monitor hepatocyte viability. Flendrig, L.M., Chamuleau, R.A., Maas, M.A., Daalhuisen, J., Hasset, B., Kilty, C.G., Doyle, S., Ladiges, N.C., Jörning, G.G., la Soe, J.W., Sommeijer, D., te Velde, A.A. J. Hepatol. (1999) [Pubmed]
  30. Operation of ion-selective electrode detectors in the sub-Nernstian/linear response range: application to flow-injection/enzymatic determination of L-glutamine in bioreactor media. Matuszewski, W., Rosario, S.A., Meyerhoff, M.E. Anal. Chem. (1991) [Pubmed]
  31. Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells. Irani, N., Beccaria, A.J., Wagner, R. J. Biotechnol. (2002) [Pubmed]
  32. Expansion in bioreactors of human progenitor populations from cord blood and mobilized peripheral blood. Van Zant, G., Rummel, S.A., Koller, M.R., Larson, D.B., Drubachevsky, I., Palsson, M., Emerson, S.G. Blood Cells (1994) [Pubmed]
  33. Anaerobic and aerobic continuous cultures of Saccharomyces cerevisiae: comparison of plasmid stability and EXG1 gene expression. Lú-Chau, T.A., Guillán, A., Núñez, M.J., Roca, E., Lema, J.M. Bioprocess and biosystems engineering. (2004) [Pubmed]
  34. Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites. Rushmore, T.H., Reider, P.J., Slaughter, D., Assang, C., Shou, M. Metab. Eng. (2000) [Pubmed]
  35. Simultaneous kinetic-based determination of fructose and ascorbate with a rotating bioreactor and amperometric detection: application to the analysis of food samples. Matsumoto, K., Baeza Baeza, J.J., Mottola, H.A. Anal. Chem. (1993) [Pubmed]
  36. A novel kringle-4 number-based recombinant apo[a] standard for human apo[a] phenotyping. Anglés-Cano, E., Loyau, S., Cardoso-Saldaña, G., Couderc, R., Gillery, P. J. Lipid Res. (1999) [Pubmed]
  37. mRNA differential display in a microbial enrichment culture: simultaneous identification of three cyclohexanone monooxygenases from three species. Brzostowicz, P.C., Walters, D.M., Thomas, S.M., Nagarajan, V., Rouvière, P.E. Appl. Environ. Microbiol. (2003) [Pubmed]
  38. Continuous glucose monitoring and control in a rotating wall perfused bioreactor. Xu, Y., Sun, J., Mathew, G., Jeevarajan, A.S., Anderson, M.M. Biotechnol. Bioeng. (2004) [Pubmed]
  39. Long-term culture of glutamine synthetase-transfected HepG2 cells in circulatory flow bioreactor for development of a bioartificial liver. Enosawa, S., Miyashita, T., Suzuki, S., Li, X.K., Tsunoda, M., Amemiya, H., Yamanaka, M., Hiramatsu, S., Tanimura, N., Omasa, T., Suga, K., Matsumura, T. Cell transplantation. (2000) [Pubmed]
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