Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Ambruticin 2-[6-[(E)-2-[2-[(1E,4E)-5-(6- ethyl-5...

Synonyms: NSC-328415, AC1NUG72, NSC328415, 58857-02-6

Williams, D.M. et al., Connor, D.T. et al., Levine, H.B. et al., Connor, D.T. et al., Julien, B. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC328415

Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin [1].
Efficacy of ambruticin analogs in a murine model of coccidioidomycosis [2].
Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis [3].
In vivo studies with ambruticin in murine histoplasmosis [4].
High-dose ambruticin (50 mg/kg of body weight every 8 hours) led to significantly prolonged survival compared to that of untreated control animals, but no long-term cures [5].

High impact information on NSC328415

Analysis of the Ambruticin and Jerangolid Gene Clusters of Sorangium cellulosum Reveals Unusual Mechanisms of Polyketide Biosynthesis [6].
Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin [7].
Nude (nu/nu) mice were infected with Histoplasma capsulatum and treated with varying doses of 3 drug regimens: oral ambruticin, intraperitoneal amphotericin B, and amphotericin B plus oral rifampin [5].

Analytical, diagnostic and therapeutic context of NSC328415

Oral administration of ambruticin (W7783) (by gavage) was lifesaving in mice infected intranasally with arthrospores of Coccidioides immitis [8].
Ambruticin S production in air-lift and stirred-tank bioreactors [9].

References

Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin. Connor, D.T., von Strandtmann, M. J. Med. Chem. (1979) [Pubmed]
Efficacy of ambruticin analogs in a murine model of coccidioidomycosis. Shubitz, L.F., Galgiani, J.N., Tian, Z.Q., Zhong, Z., Timmermans, P., Katz, L. Antimicrob. Agents Chemother. (2006) [Pubmed]
Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis. Chiang, L.Y., Ejzykowicz, D.E., Tian, Z.Q., Katz, L., Filler, S.G. Antimicrob. Agents Chemother. (2006) [Pubmed]
In vivo studies with ambruticin in murine histoplasmosis. Shadomy, S., Utz, C.J., White, S. Antimicrob. Agents Chemother. (1978) [Pubmed]
Experimental chemotherapy of histoplasmosis in nude mice. Williams, D.M., Graybill, J.R., Drutz, D.J. Am. Rev. Respir. Dis. (1979) [Pubmed]
Analysis of the Ambruticin and Jerangolid Gene Clusters of Sorangium cellulosum Reveals Unusual Mechanisms of Polyketide Biosynthesis. Julien, B., Tian, Z.Q., Reid, R., Reeves, C.D. Chem. Biol. (2006) [Pubmed]
Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin. Connor, D.T., von Strandtmann, M. J. Med. Chem. (1979) [Pubmed]
Therapeutic properties of oral ambruticin (W7783) in experimental pulmonary coccidioidomycosis of mice. Levine, H.B., Ringel, S.M., Cobb, J.M. Chest (1978) [Pubmed]
Ambruticin S production in air-lift and stirred-tank bioreactors. Hopf, N.W., Yonsel, S., Deckwer, W.D. Appl. Microbiol. Biotechnol. (1990) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.