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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Immunocytochemical localization of insulin-like growth factor I in the hypothalamo-hypophyseal system of the adult rat.

Insulin-like growth factor I (IGF-I) is shown to be involved in the regulation of pituitary hormones. High IGF-I concentrations were detected in hypothalamus and pituitary during adulthood. This study was undertaken to analyze the cellular distribution of IGF-I in the hypothalamo-hypophyseal system of the adult rat using immunocytochemical procedures. IGF-I was found to be widely distributed throughout the hypothalamus; it was present in the magnocellular neurons of the supraoptic, paraventricular, and accessory nuclei. Moreover, nerve fibres and puncta containing immunoreactive IGF-I were localized in the median eminence and the posterior lobe of the pituitary. These results support possible IGF-I neuromodulatory or neurohormonal action in the hypothalamus on pituitary hormone regulation.[1]

References

  1. Immunocytochemical localization of insulin-like growth factor I in the hypothalamo-hypophyseal system of the adult rat. Aguado, F., Fernández, T., Martínez-Murillo, R., Rodrigo, J., Cacicedo, L., Sánchez-Franco, F. Neuroendocrinology (1992) [Pubmed]
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