Disease relevance of Hypothalamo-Hypophyseal System

• Twenty-five micrograms of testosterone per kg body weight was effective to depress LH levels only in 30 day old males, suggesting a change in the hypothalamic-pituitary unit to te negative feedback of androgens [1].

High impact information on Hypothalamo-Hypophyseal System

• The presence and cell-specific localization of guanylin within the hypothalamo-hypophyseal system indicate that this peptide may be specifically involved in paracrine and endocrine regulatory mechanisms [2].
• These observations establish that feeding triggers an acute release of PRL by the hypothalamic-pituitary unit [3].
• These results indicate that XX males exhibit hypergonadotropic hypogonadism secondary to testicular failure with a preserved androgen responsiveness of the hypothalamic-pituitary unit [4].
• The greatest responses of HA to GRF-44 and SS-14 were obtained in the hypothalamo-hypophyseal system [5].
• Twenty-four-hour patterns in serum prolactin and cortisol after partial and complete isolation of the hypothalamic-pituitary unit in rhesus monkeys [6].

Biological context of Hypothalamo-Hypophyseal System

• The purpose of this study was to clarify the endocrine regulation of the adolescent menstrual cycle, especially the relationships between ovarian follicular development, luteal phase progesterone secretion, and function of the hypothalamic-pituitary unit [7].
• These data suggest: (1) that anestrus is not due to a reduction in the intrinsic ability of the hypothalamo-hypophyseal system to secrete LH, and (2) that high Prl levels may be a symptom rather than a cause of seasonal anestrus [8].
• In response to osmotic challenge, it was found that upregulation of the three CaM genes participates in the activation of the hypothalamo-hypophyseal system in the supraoptic nucleus (SON) (126% to 169%), but not in the magnocellular part of the paraventricular hypothalamic nucleus (PVN) (-10%) [9].
• The influence of the antimitotic drug CCNU on the neurosecretion of rat hypothalamo-hypophyseal system [10].

Anatomical context of Hypothalamo-Hypophyseal System

• Corticotropin-releasing hormone-containing neurons in the hypothalamo-hypophyseal system in rats six weeks after bilateral lesions of the paraventricular nucleus [11].

Associations of Hypothalamo-Hypophyseal System with chemical compounds

• Firstly, Finnish Landrace involves reducing the sensitivity of the hypothalamic-pituitary unit to the feedback effects of ovarian hormones (inhibin and/or oestradiol) which normally suppress FSH [12].
• Coexistence of salusin and vasopressin in the rat hypothalamo-hypophyseal system [13].
• Effects on circulating sex steroids were accompanied by variable effects on circulating luteinizing hormone (LH) levels, pituitary LH, and pituitary LH beta mRNA, suggesting a dual site of lead action: (a) at the level of the hypothalamic pituitary unit, and (b) directly at the level of gonadal steroid biosynthesis [14].
• Evidence for an estrogen-like action of raloxifene upon the hypothalamic-pituitary unit: raloxifene inhibits luteinizing hormone secretion and stimulates prolactin secretion in ovariectomized female rats [15].
• However, in view of markedly decreased circulating T3 concentrations and of no substantial change in the TSH pulsatile secretion in older PMW, the negative feedback on the hypothalamic-pituitary unit may be impaired in elderly women [16].

Gene context of Hypothalamo-Hypophyseal System

• These data suggest that the mechanism of adrenal activation by chlordecone may possess a direct component, in addition to the well-characterized stimulation of pituitary ACTH secretion caused by chlordecone acting on the hypothalamo-hypophyseal system [17].
• Effect of ethanol and acetaldehyde on the release of arginine-vasopressin and oxytocin from the isolated hypothalamo-hypophyseal system of rats [18].
• This study was undertaken to analyze the cellular distribution of IGF-I in the hypothalamo-hypophyseal system of the adult rat using immunocytochemical procedures [19].
• Galanin in the hypothalamo-hypophyseal system [20].
• Cholecystokinin in the hypothalamo-hypophyseal system [21].

Analytical, diagnostic and therapeutic context of Hypothalamo-Hypophyseal System

• Afterwards vasopressin production in the hypothalamo-hypophyseal system was analysed by the immunoperoxidase technique and a microdensitometric method [22].

References