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MeSH Review

Median Eminence

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Disease relevance of Median Eminence


Psychiatry related information on Median Eminence


High impact information on Median Eminence


Chemical compound and disease context of Median Eminence


Biological context of Median Eminence

  • The tight link between GAL and LHRH neuronal systems is strengthened by the observation that during the estrous cycle of the rat, rGAL and LHRH contents in the median eminence show an identical profile (r = 1.00) [18].
  • Our previous studies have shown that stimulation of the anteroventral third ventricle (AV3V) region of the brain increases atrial natriuretic peptide (ANP) release, whereas lesions of the AV3V region or median eminence of the tuber cinereum block the release of ANP caused by blood volume expansion [19].
  • The presence of putative melatonin receptors in the suprachiasmatic nuclei and median eminence of these rodent species suggests that these brain regions are important loci for melatonin effects on circadian rhythms and reproduction [20].
  • The mRNA encoding vasopressin has recently been documented within the magnocellular hypothalamo-neurohypophyseal projections of the rat such as the median eminence (ME) and the posterior pituitary (PP), suggesting the possibility of its axonal transport [21].
  • The six classic phenotypes were identified in histological sections with rabbit antisera to neurotransmitters (or related enzymes), nuclear bromodeoxyuridine was detected with a mouse monoclonal antibody, and an axonal projection to the median eminence was determined with the fluorescent retrograde tracer fast blue [22].

Anatomical context of Median Eminence


Associations of Median Eminence with chemical compounds


Gene context of Median Eminence

  • This may reflect lateralized hypothalamic and/or suprahypothalamic function resulting in CRH-responsive lateralized secretion of AVP from parvocellular and/or magnocellular axons in the median eminence and the posterior pituitary [31].
  • Exogenous administration of leptin to fasted animals restored PC1 levels in the median eminence (ME) and the PVN to approximately the level found in fed control animals [32].
  • CRF receptor expression in hypothalamic neurosecretory structures, including the paraventricular nucleus and median eminence, is generally low [33].
  • Moreover, B or T MPOA implants also decreased resting-state levels of AVP but not CRH in the median eminence, and these effects were correlated with ACTH responses to restraint [34].
  • Infundibular nucleus (including median eminence) NPY ICC staining or mRNA expression, and AGRP ICC staining, increased with premorbid illness duration [35].

Analytical, diagnostic and therapeutic context of Median Eminence


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  14. Hypoglycemia enhances turnover of corticotropin-releasing factor and of vasopressin in the zona externa of the rat median eminence. Berkenbosch, F., De Goeij, D.C., Tilders, F.J. Endocrinology (1989) [Pubmed]
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  22. Spatiotemporal patterns of secretomotor neuron generation in the parvicellular neuroendocrine system. Markakis, E.A., Swanson, L.W. Brain Res. Brain Res. Rev. (1997) [Pubmed]
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  27. Characterization of cDNA for precursor of human luteinizing hormone releasing hormone. Seeburg, P.H., Adelman, J.P. Nature (1984) [Pubmed]
  28. Fluorescence-immunocytochemistry: simultaneous localization of catecholamines and gonadotropin-releasing hormone. McNeill, T.H., Sladek, J.R. Science (1978) [Pubmed]
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  32. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. Sanchez, V.C., Goldstein, J., Stuart, R.C., Hovanesian, V., Huo, L., Munzberg, H., Friedman, T.C., Bjorbaek, C., Nillni, E.A. J. Clin. Invest. (2004) [Pubmed]
  33. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Potter, E., Sutton, S., Donaldson, C., Chen, R., Perrin, M., Lewis, K., Sawchenko, P.E., Vale, W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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