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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Indomethacin and ethamsylate alone and in combination for the relief of post episiotomy pain.

In a bid to minimise dosage and possible side-effects when relieving post episiotomy pain, the NSAID Indomethacin was studied in combination with a systemic haemostat Ethamsylate which has been shown to selectively inhibit some prostaglandins. Comparative groups also took Indomethacin alone and placebo in a double blind non-crossover comparison. Efficacy was judged in terms of side-effects and assessments of pain intensity, pain relief and global assessment of pain. There was some evidence of a beneficial interaction between Indomethacin and Ethamsylate when adjustments were made for the patient's age and initial pain score. Side-effects were most common in the combination therapy group.[1]

References

  1. Indomethacin and ethamsylate alone and in combination for the relief of post episiotomy pain. Harrison, R.F., Devitt, M. Irish journal of medical science. (1992) [Pubmed]
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