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Chemical Compound Review

AC1OAGLE     1-[1-(4- chlorophenyl)carbonyl-5- methoxy-2...

Synonyms: SureCN5534201
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Disease relevance of indomethacin


Psychiatry related information on indomethacin


High impact information on indomethacin


Chemical compound and disease context of indomethacin


Biological context of indomethacin


Anatomical context of indomethacin


Associations of indomethacin with other chemical compounds


Gene context of indomethacin

  • Acetaminophen and indomethacin also permitted 18R-HEPE and 15R-HEPE generation with recombinant COX-2 as well as omega-5 and omega-9 oxygenations of other fatty acids that act on hematologic cells [28].
  • Furthermore, indomethacin (but not catalase or PMA) considerably augmented IL-2 secretion of Con A-stimulated BB spleen cells, but had little effect on WF spleen cells [29].
  • The differential TNF-alpha production by astrocytes from BN and Lewis strains is not due to the suppressive effect of prostaglandins, because the addition of indomethacin does not alter the differential pattern of TNF-alpha expression [30].
  • Thus, pretreatment of platelets with the cyclooxygenase (COX) inhibitor, indomethacin (20 microM), the thromboxane antagonist SQ29,548 (1 microM), or the protein kinase C inhibitor GF109203X (5 microM) prevents platelet activation by microparticles [31].
  • Indomethacin, an inhibitor of Cox-1 and Cox-2, further reduced the number of surviving crypts in irradiated mice [32].

Analytical, diagnostic and therapeutic context of indomethacin


  1. Prophylactic indomethacin for patent ductus arteriosus. Sweet, A.Y. N. Engl. J. Med. (1982) [Pubmed]
  2. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. Schmidt, B., Davis, P., Moddemann, D., Ohlsson, A., Roberts, R.S., Saigal, S., Solimano, A., Vincer, M., Wright, L.L. N. Engl. J. Med. (2001) [Pubmed]
  3. Neonatal complications after the administration of indomethacin for preterm labor. Norton, M.E., Merrill, J., Cooper, B.A., Kuller, J.A., Clyman, R.I. N. Engl. J. Med. (1993) [Pubmed]
  4. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. Robertson, R.M., Robertson, D., Roberts, L.J., Maas, R.L., FitzGerald, G.A., Friesinger, G.C., Oates, J.A. N. Engl. J. Med. (1981) [Pubmed]
  5. Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion. Wei, W.Z., Fulton, A., Winkelhake, J., Heppner, G. Cancer Res. (1989) [Pubmed]
  6. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Sung, S., Yang, H., Uryu, K., Lee, E.B., Zhao, L., Shineman, D., Trojanowski, J.Q., Lee, V.M., Praticò, D. Am. J. Pathol. (2004) [Pubmed]
  7. Central nervous system side effects of nonsteroidal anti-inflammatory drugs. Aseptic meningitis, psychosis, and cognitive dysfunction. Hoppmann, R.A., Peden, J.G., Ober, S.K. Arch. Intern. Med. (1991) [Pubmed]
  8. Sustained-release indomethacin in the management of ankylosing spondylitis. Calabro, J.J. Am. J. Med. (1985) [Pubmed]
  9. Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats. Rao, S.K., Andrade, C., Reddy, K., Madappa, K.N., Thyagarajan, S., Chandra, S. Biol. Psychiatry (2002) [Pubmed]
  10. Ibuprofen versus indomethacin for closure of patent ductus arteriosus. Casalaz, D. N. Engl. J. Med. (2001) [Pubmed]
  11. A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. Van Overmeire, B., Smets, K., Lecoutere, D., Van de Broek, H., Weyler, J., Degroote, K., Langhendries, J.P. N. Engl. J. Med. (2000) [Pubmed]
  12. Nephrogenic diabetes insipidus responsive to indomethacin plus dDAVP. Stasior, D.S., Kikeri, D., Duel, B., Seifter, J.L. N. Engl. J. Med. (1991) [Pubmed]
  13. Prostaglandin-producing suppressor cells in Hodgkin's disease. Goodwin, J.S., Messner, R.P., Bankhurst, A.D., Peake, G.T., Saiki, J.H., Williams, R.C. N. Engl. J. Med. (1977) [Pubmed]
  14. Irreversible renal failure after indomethacin in steroid-resistant nephrosis. Kleinknecht, C., Broyer, M., Gubler, M.C., Palcoux, J.B. N. Engl. J. Med. (1980) [Pubmed]
  15. 15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. Paul-Clark, M.J., Van Cao, T., Moradi-Bidhendi, N., Cooper, D., Gilroy, D.W. J. Exp. Med. (2004) [Pubmed]
  16. Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart. Alexander, R.W., Kent, K.M., Pisano, J.J., Keiser, H.R., Cooper, T. J. Clin. Invest. (1975) [Pubmed]
  17. Regulation of human B cell activation by prostaglandin E2. Suppression of the generation of immunoglobulin-secreting cells. Jelinek, D.F., Thompson, P.A., Lipsky, P.E. J. Clin. Invest. (1985) [Pubmed]
  18. Coronary vasoconstriction caused by indomethacin. O'Brien, W.M. N. Engl. J. Med. (1982) [Pubmed]
  19. Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus. Brash, A.R., Hickey, D.E., Graham, T.P., Stahlman, M.T., Oates, J.A., Cotton, R.B. N. Engl. J. Med. (1981) [Pubmed]
  20. Coronary vascular reactivity after acute myocardial ischemia. Ku, D.D. Science (1982) [Pubmed]
  21. Specific inhibition of lymphocyte-proliferation responses by adherent suppressor cells in diffuse cutaneous leishmaniasis. Petersen, E.A., Neva, F.A., Oster, C.N., Bogaert Diaz, H. N. Engl. J. Med. (1982) [Pubmed]
  22. Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. Moise, K.J., Huhta, J.C., Sharif, D.S., Ou, C.N., Kirshon, B., Wasserstrum, N., Cano, L. N. Engl. J. Med. (1988) [Pubmed]
  23. Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease. Friedman, P.L., Brown, E.J., Gunther, S., Alexander, R.W., Barry, W.H., Mudge, G.H., Grossman, W. N. Engl. J. Med. (1981) [Pubmed]
  24. Hydroxyl radical scavengers inhibit human natural killer cell activity. Suthanthiran, M., Solomon, S.D., Williams, P.S., Rubin, A.L., Novogrodsky, A., Stenzel, K.H. Nature (1984) [Pubmed]
  25. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Kurumbail, R.G., Stevens, A.M., Gierse, J.K., McDonald, J.J., Stegeman, R.A., Pak, J.Y., Gildehaus, D., Miyashiro, J.M., Penning, T.D., Seibert, K., Isakson, P.C., Stallings, W.C. Nature (1996) [Pubmed]
  26. Prostaglandin synthetase inhibitors in Bartter's syndrome. Effect on immunoreactive prostaglandin E excretion. Bowden, R.E., Gill, J.R., Radfar, N., Taylor, A.A., Keiser, H.R. JAMA (1978) [Pubmed]
  27. Immune regulation of the L5178Y murine tumor-dormant state. I. In vivo and in vitro effects of prostaglandin E2 and indomethacin on tumor cell growth. Liu, C.M., Okayasu, T., Goldman, P., Suzuki, Y., Suzuki, K., Wheelock, E.F. J. Exp. Med. (1986) [Pubmed]
  28. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. Serhan, C.N., Clish, C.B., Brannon, J., Colgan, S.P., Chiang, N., Gronert, K. J. Exp. Med. (2000) [Pubmed]
  29. Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages. Prud'homme, G.J., Fuks, A., Colle, E., Seemayer, T.A., Guttmann, R.D. J. Exp. Med. (1984) [Pubmed]
  30. Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains. Chung, I.Y., Norris, J.G., Benveniste, E.N. J. Exp. Med. (1991) [Pubmed]
  31. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. Barry, O.P., Pratico, D., Lawson, J.A., FitzGerald, G.A. J. Clin. Invest. (1997) [Pubmed]
  32. Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1. Cohn, S.M., Schloemann, S., Tessner, T., Seibert, K., Stenson, W.F. J. Clin. Invest. (1997) [Pubmed]
  33. Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants. Mahony, L., Carnero, V., Brett, C., Heymann, M.A., Clyman, R.I. N. Engl. J. Med. (1982) [Pubmed]
  34. Indomethacin-induced hyperkalemia in three patients with gouty arthritis. Findling, J.W., Beckstrom, D., Rawsthorne, L., Kozin, F., Itskovitz, H. JAMA (1980) [Pubmed]
  35. Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep. Robinson, D.R., Skoskiewicz, M., Bloch, K.J., Castorena, G., Hayes, E., Lowenstein, E., Melvin, C., Michelassi, F., Zapol, W.M. J. Exp. Med. (1986) [Pubmed]
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