- EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Kleer, C.G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S.A., Ghosh, D., Sewalt, R.G., Otte, A.P., Hayes, D.F., Sabel, M.S., Livant, D., Weiss, S.J., Rubin, M.A., Chinnaiyan, A.M. Proc. Natl. Acad. Sci. U.S.A. (2003)