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Rho, M.C. et al.

Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki.

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL.[1]

References

Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki. Rho, M.C., Chung, M.Y., Song, H.Y., Kwon, O.E., Lee, S.W., Baek, J.A., Jeune, K.H., Kim, K., Lee, H.S., Kim, Y.K. Arch. Pharm. Res. (2003) [Pubmed]

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