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Controlled release of vitamin E from thermo-responsive polymeric physico-gel.

Thermo-sensitive copolymer consists of poly(2-ethoxyethyl vinyl ether) and poly(hydroxyethyl vinyl ether) (EOVE200-HOVE400), whose sol-gel transition temperature was 20.5 degrees C, was synthesized and its applicability to a drug delivery system was examined. Vitamin E (VE) was enclosed in EOVE200-HOVE400 and the release of VE was measured by varying the temperature 10<-->30 degrees C. There was no release of VE from EOVE200-HOVE400 at 30 degrees C, while VE was released when the temperature was reduced to 10 degrees C.[1]

References

  1. Controlled release of vitamin E from thermo-responsive polymeric physico-gel. Ishida, M., Sakai, H., Sugihara, S., Aoshima, S., Yokoyama, S., Abe, M. Chem. Pharm. Bull. (2003) [Pubmed]
 
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