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Chemical Compound Review:

Dal-E 4-oxo-4-[(2R)-2,5,7,8- tetramethyl-2-[(4R...

Synonyms: Covitol 1210, CHEMBL81421, SureCN134422, Vitamin-E Dragees, tocopherol succinate, ...

Kim, S.J. et al., Larrosa, J.M. et al., Yu, W. et al., Lee, J.K. et al., Bang, O.S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Vitamine E succinate

Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis [1].
RESULTS: Alpha-tocopherol and alpha-tocopheryl-acid-succinate in saline solution delayed development of proliferative vitreoretinopathy, compared to the control group (statistically significant during the first week, Mann Whitney, p < 0.05) [2].
CONCLUSIONS: Alpha-tocopherol and alpha-tocopheryl-acid-succinate in saline solution showed retardation of proliferative vitreoretinopathy traction retinal detachments [2].

High impact information on Vitamine E succinate

During monocytic differentiation of U937 cells induced by vitamin E-succinate and/or fibronectin, nitric oxide was detected in supernatants [3].
Production of inducible nitric oxide is required for monocytic differentiation of U937 cells induced by vitamin E-succinate [3].
Vitamin E-succinate is known to be a potent modulator of haematopoietic differentiation as well as an inhibitor of cell growth in vitro and in vivo [3].
Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells [4].

Gene context of Vitamine E succinate

Expression of p21WAF1 is dependent on the activation of ERK during vitamin E-succinate-induced monocytic differentiation [5].
Vitamin E-succinate and/or fibronectin induced monocytic differentiation was blocked by the treatment of nitric oxide synthase inhibitor, N-G-monomethyl-L-arginine [3].

References

Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. Yu, W., Israel, K., Liao, Q.Y., Aldaz, C.M., Sanders, B.G., Kline, K. Cancer Res. (1999) [Pubmed]
Antiproliferative effect of intravitreal alpha-tocopherol and alpha-tocopheryl-acid-succinate in a rabbit model of PVR. Larrosa, J.M., Veloso, A.A., Leong, F.L., Refojo, M.F. Curr. Eye Res. (1997) [Pubmed]
Production of inducible nitric oxide is required for monocytic differentiation of U937 cells induced by vitamin E-succinate. Kim, S.J., Bang, O.S., Lee, Y.S., Kang, S.S. J. Cell. Sci. (1998) [Pubmed]
Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Bang, O.S., Park, J.H., Kang, S.S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
Expression of p21WAF1 is dependent on the activation of ERK during vitamin E-succinate-induced monocytic differentiation. Lee, J.K., Jung, J.C., Chun, J.S., Kang, S.S., Bang, O.S. Mol. Cells (2002) [Pubmed]

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