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Hall, A.J. et al.

Hall, Achilli, Manesiotis, Quaglia, De Lorenzi, Sellergren,

A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules.

The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.[1]

References

A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules. Hall, A.J., Achilli, L., Manesiotis, P., Quaglia, M., De Lorenzi, E., Sellergren, B. J. Org. Chem. (2003) [Pubmed]

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