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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Phenotype of endomyocardial biopsy-derived T-lymphocyte cultures and chronic rejection after heart transplantation.

Chronic rejection (CR) is a major problem in long-term survival in heart transplantation. We analysed whether the occurrence of CR correlates with the incidence of acute rejections (AR) or with characteristics of endomyocardial biopsy-derived cell cultures. CR was diagnosed by annual angiography and defined as all coronary vascular changes. One year after transplantation 24 of the 63 patients had CR (38%). The incidence of AR in CR+ and CR- patients was comparable. The patients in both groups had similar individual median percentages of EMB-yielding cell cultures. During the first year the CR- patients had more cultures in which at least 60% of the cells were CD4+ T cells (50% vs 37%, P = 0.05), due to a stronger CD4 predominance in the first 6 months. In the second year the CD4 predominance in the patients diagnosed as CR+ after 1 year tended to be higher (P = 0.08). The patients had comparable percentages of cultures predominated by CD8+ T cells, gammadelta T cells or NK cells, irrespective of the time interval. These results might indicate that CD4+ T lymphocytes play a dual role in the aetiology of CR.[1]

References

  1. Phenotype of endomyocardial biopsy-derived T-lymphocyte cultures and chronic rejection after heart transplantation. Groeneveld, K., Balk, A.H., Ouwehand, A.J., Loonen, E.H., v d Linden, M., Strikwerda, S., Mochtar, B., Jutte, N.H., Weimar, W. Transpl. Int. (1992) [Pubmed]
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