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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Levetiracetam treatment of idiopathic generalised epilepsy.

Levetiracetam (LEV) is effective for treating localisation-related epilepsy, but it is uncertain whether it is effective for treating idiopathic generalised epilepsy. We compared 12-week baseline and LEV treatment periods for patients with generalised seizure types-myoclonic, tonic-clonic and absence seizures--who had failed other anticonvulsants. The majority of 55 patients (76%) had >50% seizure reduction with LEV therapy, 40% became seizure-free; 15% discontinued LEV due to adverse events, mostly sedation. This is preliminary evidence that LEV is effective for treating idiopathic generalised epilepsy.[1]


  1. Levetiracetam treatment of idiopathic generalised epilepsy. Krauss, G.L., Betts, T., Abou-Khalil, B., Gergey, G., Yarrow, H., Miller, A. Seizure : the journal of the British Epilepsy Association. (2003) [Pubmed]
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