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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.

The transcription factor nuclear factor kappaB (NF-kappaB) is a pleiotropic protein complex that is activated from a sequestered, cytoplasmic form by pro-inflammatory extracellular signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kappaB, including cytokines, chemokines and adhesion molecules. Nearly eight years ago, a flurry of publications showed that loss or suppression of NF-kappaB results in an enhanced sensitivity to apoptosis. In the ensuing years, activation of NF-kappaB has become almost synonymous with enhanced cell survival, although more recent data suggests that this transcription factor plays a more complex role in the regulation of cell death.[1]

References

  1. Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Burstein, E., Duckett, C.S. Curr. Opin. Cell Biol. (2003) [Pubmed]
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