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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway.

Infectious entry of JC virus (JCV) into human glial cells occurs by receptor-mediated clathrin-dependent endocytosis. In this report we demonstrate that the tyrosine kinase inhibitor genistein blocks virus entry and inhibits infection. Transient expression of dominant-negative eps15 mutants, including a phosphorylation-defective mutant, inhibited both virus entry and infection. We also show that the JCV-induced signal activates the mitogen-activated protein kinases ERK1 and ERK2. These data demonstrate that JC virus binding to human glial cells induces an intracellular signal that is critical for entry and infection by a ligand-inducible clathrin-dependent mechanism.[1]

References

  1. A JC virus-induced signal is required for infection of glial cells by a clathrin- and eps15-dependent pathway. Querbes, W., Benmerah, A., Tosoni, D., Di Fiore, P.P., Atwood, W.J. J. Virol. (2004) [Pubmed]
 
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