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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation.

Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies.[1]

References

  1. Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation. Salinger, W.L., Ladrow, P., Wheeler, C. Behav. Neurosci. (2003) [Pubmed]
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