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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of hydrogen peroxide on sodium current in acutely isolated rat hippocampal CA1 neurons.

The effects of hydrogen peroxide (H2O2) on sodium currents (Na+ currents) in freshly dissociated rat hippocampal neurons were studied using the whole-cell patch-clamp techniques. H2O2 caused a reversible increase of the voltage-activated Na+ currents in a concentration- and voltage-dependent manner. The half-increasing concentration (EC50) of H2O2 on Na+ currents was 10.79 microM. In addition, 10 microM H2O2 shifted the steady-state inactivation curve of Na+ currents toward positive potential (control Vh = -64.58 +/- 1.22 mV, H2O2 Vh = -53.55 +/- 0.94 mV, n = 10, P < 0.01 without changing the slope factor). However, the steady-state activation curve was not affected. These results indicated that H2O2 could increase the amplitudes of Na+ currents and change the inactivation properties of Na+ channels even in very low concentration.[1]


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