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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Sodium valproate in Huntington's disease.

The authors assessed the effect of sodium valproate, which is thought to elevate brain gamma-aminobutyric acid (GABA) levels, in the treatment of Huntington's disease by an objective ultrasound method in three patients with Huntington's disease. Despite plasma levels ranging from 47.0 to 140.8 microgram/ml (mean, 104.7), sodium valproate had no beneficial effect on involuntary movements. The authors stress the importance of activation to achieve a standard level of arousal in the assessment of involuntary movements.[1]


  1. Sodium valproate in Huntington's disease. Symington, G.R., Leonard, D.P., Shannon, P.J., Vajda, F.J. The American journal of psychiatry. (1978) [Pubmed]
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