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Seniów, J. et al.

Seniów, Mroziak, Członkowska, Jedryka-Góral,

Self-rated emotional functioning of patients with neurological or asymptomatic form of Wilson's disease.

Psychopathology was assessed in 50 patients with the neurological form of Wilson's disease (WD-N) and in 17 asymptomatic patients (WD-A) compared to matched healthy controls and to rheumatoid arthritis ( RA) control patients using The Hopkins Symptom Checklist. As hypothesized, WD-N patients had significantly lower interpersonal sensitivity and aggression/hostility scores than had healthy controls, but did not differ from them either in depression or anxiety levels. Retarded depression and anxiety were higher among RA patients than in WD-N patients. This nondistressed response to the chronic disabling disease was even more salient in 19 WD patients with lesions in basal ganglia only. WD-A patients did not differ from their healthy peers, which suggests a tendency towards hypercompensation and denial in the former. WD-N patients' limited awareness of their deficits (including impaired control of affective behavior) seems to result from their brain damage implicating the basal ganglia.[1]

References

Self-rated emotional functioning of patients with neurological or asymptomatic form of Wilson's disease. Seniów, J., Mroziak, B., Członkowska, A., Jedryka-Góral, A. The Clinical neuropsychologist. (2003) [Pubmed]

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